公开(公告)号：US08442608B2

公开(公告)日：2013-05-14

申请号：US12343838

申请日：2008-12-24

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/1455

CPC分类号： A61B5/6826 ,  A61B5/02416 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6838 ,  G06K9/00496

摘要： There is disclosed a system and methods to estimate physiological parameters. In accordance with embodiments a method is disclosed which includes generating distribution data for a plurality of signals. The method may also include deconvolving one of the plurality of signals from the other plurality of signals to produce clean signals. The clean signals may then be used to calculate physiological parameters.

摘要翻译： 公开了一种估计生理参数的系统和方法。 根据实施例公开了一种方法，其包括生成多个信号的分配数据。 该方法还可以包括对来自其它多个信号的多个信号之一解卷积以产生清洁信号。 然后可以使用干净的信号来计算生理参数。

公开(公告)号：US20090248320A1

公开(公告)日：2009-10-01

申请号：US12412947

申请日：2009-03-27

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： G01J3/40 ,  G06F19/00

CPC分类号： G06K9/624 ,  G01J3/28

摘要： Systems and methods for unmixing spectroscopic data using nonnegative matrix factorization during spectrographic data processing are provided according to various embodiments. In an embodiment, a method of processing spectrographic data may include receiving optical absorbance data associated with a sample and iteratively computing values for component spectra using nonnegative matrix factorization. The values for component spectra may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of a pathlength matrix and a matrix product of a concentration matrix and a component spectra matrix. The method may also include iteratively computing values for pathlength using nonnegative matrix factorization, in which pathlength values may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of the pathlength matrix and the matrix product of the concentration matrix and the component spectra matrix.

摘要翻译： 根据各种实施例提供了在光谱数据处理期间使用非负矩阵分解的解混光谱数据的系统和方法。 在一个实施例中，处理光谱数据的方法可以包括接收与样本相关联的光吸收数据，并且使用非负矩阵因子分解迭代地计算分量光谱的值。 可以迭代地计算分量光谱的值，直到光吸收数据近似等于路径长度矩阵的Hadamard乘积和浓度矩阵和分量光谱矩阵的矩阵乘积。 该方法还可以包括使用非负矩阵因式分解来迭代地计算路径长度的值，其中可以迭代地计算路径长度值，直到光吸收数据近似等于路径长度矩阵的Hadamard乘积和浓度矩阵的矩阵积与分量光谱 矩阵。

公开(公告)号：US20090247844A1

公开(公告)日：2009-10-01

申请号：US12412956

申请日：2009-03-27

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551

摘要： Embodiments disclosed herein may include methods and systems capable of estimating the underlying concentrations of chromophores in a sample. The photon scattering and absorption model may be based on Laplace and stable distributions, which may reveal that measurements in diffuse reflectance may follow a Beer-Lambert and Kohlrausch-Williams-Watts (KWW) product. This Beer-Lambert portion of the product may dominate in high absorption sample areas, while the KWW portion of the product may dominate in low absorption sample areas.

摘要翻译： 本文公开的实施方案可以包括能够估计样品中发色团的潜在浓度的方法和系统。 光子散射和吸收模型可以基于拉普拉斯和稳定分布，这可以揭示漫反射中的测量可以遵循Beer-Lambert和Kohlrausch-Williams-Watts（KWW）产物。 该产品的Beer-Lambert部分可能在高吸收样品区域占主导地位，而KWW部分产品可能在低吸收样品区域占主导地位。

公开(公告)号：US08140272B2

公开(公告)日：2012-03-20

申请号：US12412947

申请日：2009-03-27

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： G06F19/00 ,  G01J3/40

CPC分类号： G06K9/624 ,  G01J3/28

摘要： Systems and methods for unmixing spectroscopic data using nonnegative matrix factorization during spectrographic data processing are provided according to various embodiments. In an embodiment, a method of processing spectrographic data may include receiving optical absorbance data associated with a sample and iteratively computing values for component spectra using nonnegative matrix factorization. The values for component spectra may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of a pathlength matrix and a matrix product of a concentration matrix and a component spectra matrix. The method may also include iteratively computing values for pathlength using nonnegative matrix factorization, in which pathlength values may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of the pathlength matrix and the matrix product of the concentration matrix and the component spectra matrix.

摘要翻译： 根据各种实施例提供了在光谱数据处理期间使用非负矩阵分解的解混光谱数据的系统和方法。 在一个实施例中，处理光谱数据的方法可以包括接收与样本相关联的光吸收数据，并且使用非负矩阵因子分解迭代地计算分量光谱的值。 可以迭代地计算分量光谱的值，直到光吸收数据近似等于路径长度矩阵的Hadamard乘积和浓度矩阵和分量光谱矩阵的矩阵乘积。 该方法还可以包括使用非负矩阵因式分解来迭代地计算路径长度的值，其中可以迭代地计算路径长度值，直到光吸收数据近似等于路径长度矩阵的Hadamard乘积和浓度矩阵的矩阵积与分量光谱 矩阵。

公开(公告)号：US08064975B2

公开(公告)日：2011-11-22

申请号：US11524167

申请日：2006-09-20

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/0261

摘要： Embodiments of the present invention relate to a method of estimating a blood flow characteristic in a patient. Present embodiments include providing a first probability distribution for an actual value of a function of the blood flow characteristic based on a previous value of the function, providing a second probability distribution describing a probability that observations of the blood flow characteristic were made given that the blood flow characteristic took a certain value, and combining the first and second probability distributions to facilitate selection of a most likely value of the function for posting as the value of the estimated blood flow characteristic.

摘要翻译： 本发明的实施例涉及一种估计患者血流特性的方法。 目前的实施例包括基于功能的先前值来提供血液流动特征的功能的实际值的第一概率分布，提供第二概率分布，其描述了血液流动特征的观察结果， 流量特性取一定的值，并且组合第一和第二概率分布以便于选择用于发布的功能的最可能的值作为估计的血流特性的值。

公开(公告)号：US20090187085A1

公开(公告)日：2009-07-23

申请号：US12343838

申请日：2008-12-24

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/1455 ,  G06F19/00

CPC分类号： A61B5/6826 ,  A61B5/02416 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6838 ,  G06K9/00496

摘要： There is disclosed a system and methods to estimate physiological parameters. In accordance with embodiments a method is disclosed which includes generating distribution data for a plurality of signals. The method may also include deconvolving one of the plurality of signals from the other plurality of signals to produce clean signals. The clean signals may then be used to calculate physiological parameters.

摘要翻译： 公开了一种估计生理参数的系统和方法。 根据实施例公开了一种方法，其包括生成多个信号的分配数据。 该方法还可以包括对来自其它多个信号的多个信号之一解卷积以产生清洁信号。 然后可以使用干净的信号来计算生理参数。

公开(公告)号：US20120143026A1

公开(公告)日：2012-06-07

申请号：US13278057

申请日：2011-10-20

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/026 ,  A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/0261

摘要： Present embodiments include providing an initial estimate of a value representative of a blood flow characteristic at a current timestep, and determining a probability distribution of transition, wherein the probability distribution of transition includes potential values of the blood flow characteristic at the current timestep with associated probabilities of occurrence based solely on the initial estimate. Present embodiments further include obtaining an initial measurement of the blood flow characteristic, and determining a probability distribution of measured values, wherein the probability distribution of measured values includes potential values of the blood flow characteristic at the current timestep with associated probabilities of occurrence based on the initial measurement. Further, present embodiments include combining the probability of distribution of transition with the probability of distribution of measured values to determine a meaningful blood flow characteristic value, and posting the meaningful blood flow characteristic value.

摘要翻译： 现有实施例包括提供代表当前时间步长的血流特性的值的初始估计，以及确定转换的概率分布，其中转换的概率分布包括当前时间步长处的血流特征的潜在值，具有相关概率 仅基于初始估计的发生。 本实施例还包括获得血流特性的初始测量，以及确定测量值的概率分布，其中测量值的概率分布包括当前时间步长的血液流动特征的潜在值，其中相关联的发生概率基于 初始测量。 此外，本实施例包括将转移分布的概率与测量值的分布概率组合以确定有意义的血流特征值，并且发布有意义的血流特性值。

公开(公告)号：US07848891B2

公开(公告)日：2010-12-07

申请号：US11540170

申请日：2006-09-29

申请人： Paul D. Mannheimer ,  Steven E. Pav

发明人： Paul D. Mannheimer ,  Steven E. Pav

IPC分类号： G06F19/00 ,  G01N33/50 ,  A61B5/0295

CPC分类号： A61B5/6826 ,  A61B5/14551 ,  A61B5/6838

摘要： Embodiments of the present invention relate to a system and method for detecting a blood characteristic in a patient. Embodiments of the present invention may comprise detecting a first modulating signal at a first wavelength, detecting a second modulating signal at a second wavelength, and determining a relative amplitude of the first and second modulating signals. Further, embodiments of the present invention may comprise regressing the first and second modulating signals relative to one another, wherein a first uncertainty value in the first modulating signal and a second uncertainty value in the second modulating signal are accommodated.

摘要翻译： 本发明的实施例涉及一种用于检测患者血液特性的系统和方法。 本发明的实施例可以包括检测第一波长的第一调制信号，检测第二波长的第二调制信号，以及确定第一和第二调制信号的相对幅度。 此外，本发明的实施例可以包括相对于彼此回归第一和第二调制信号，其中容纳第一调制信号中的第一不确定性值和第二调制信号中的第二不确定性值。

公开(公告)号：US20080081974A1

公开(公告)日：2008-04-03

申请号：US11529939

申请日：2006-09-29

申请人： Steven E. Pav

发明人： Steven E. Pav

IPC分类号： A61B5/1455

CPC分类号： G16H50/20 ,  G06F19/00

摘要： A method of manufacturing a pulse oximeter configured to classify patient data is disclosed. The method includes collecting a set of sample data and classifying the sample data as either pathological or normal using human expertise. The method also includes generating statistics representative of the saturation traces. A linear discriminator is composed having a non-linear transform that accepts the statistics as input and a pulse oximeter is programmed to compute the linear discriminator using a kernel function.

摘要翻译： 公开了一种制造用于对患者数据进行分类的脉搏血氧计的制造方法。 该方法包括收集一组样本数据，并使用人类专长将样本数据分类为病理或正常。 该方法还包括生成表示饱和度曲线的统计信息。 组合线性鉴别器具有接受统计作为输入的非线性变换，并且脉冲血氧计被编程为使用核函数来计算线性鉴别器。

公开(公告)号：US20080081325A1

公开(公告)日：2008-04-03

申请号：US11540170

申请日：2006-09-29

申请人： Paul D. Mannheimer ,  Steven E. Pav

发明人： Paul D. Mannheimer ,  Steven E. Pav

IPC分类号： G06F19/00 ,  C12Q1/00

CPC分类号： A61B5/6826 ,  A61B5/14551 ,  A61B5/6838

摘要： Embodiments of the present invention relate to a system and method for detecting a blood characteristic in a patient. Embodiments of the present invention may comprise detecting a first modulating signal at a first wavelength, detecting a second modulating signal at a second wavelength, and determining a relative amplitude of the first and second modulating signals. Further, embodiments of the present invention may comprise regressing the first and second modulating signals relative to one another, wherein a first uncertainty value in the first modulating signal and a second uncertainty value in the second modulating signal are accommodated.

摘要翻译： 本发明的实施例涉及一种用于检测患者血液特性的系统和方法。 本发明的实施例可以包括检测第一波长的第一调制信号，检测第二波长的第二调制信号，以及确定第一和第二调制信号的相对幅度。 此外，本发明的实施例可以包括相对于彼此回归第一和第二调制信号，其中容纳第一调制信号中的第一不确定性值和第二调制信号中的第二不确定性值。