公开(公告)号：US20140371542A1

公开(公告)日：2014-12-18

申请号：US14343085

申请日：2012-09-05

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61M5/42 ,  A61M37/00 ,  A61B19/00 ,  A61M5/50

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的用于振动的杆或光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在器械前端上的尖端套管和可拆卸地安装在突出的杆或光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US09675766B2

公开(公告)日：2017-06-13

申请号：US14343085

申请日：2012-09-05

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61B1/06 ,  A61M5/42 ,  A61M5/50 ,  A61M37/00 ,  A61B90/30

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

公开(公告)号：US09168340B2

公开(公告)日：2015-10-27

申请号：US13253572

申请日：2011-10-05

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61H1/00 ,  A61M5/42 ,  A61B19/00 ,  A61M5/50 ,  A61M37/00

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的用于振动的杆或光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在仪器前端上的尖端套管和可拆卸地安装在突出的杆或光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US20120029422A1

公开(公告)日：2012-02-02

申请号：US13253572

申请日：2011-10-05

申请人： Steven GOLDBERG ,  Michael Goldberg ,  David Schiff

发明人： Steven GOLDBERG ,  Michael Goldberg ,  David Schiff

IPC分类号： A61M5/42

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的用于振动的杆或光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在仪器前端上的尖端套管和可拆卸地安装在突出的杆或光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US08622952B2

公开(公告)日：2014-01-07

申请号：US13225782

申请日：2011-09-06

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61B17/20

CPC分类号： A61M5/422 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的光管从前端突出。 所述制品是单个使用的尖端，由可移除地安装在所述器械前端上的尖端套管和可移除地安装在所述突出的光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US20110319812A1

公开(公告)日：2011-12-29

申请号：US13225782

申请日：2011-09-06

申请人： Steven GOLDBERG ,  Michael Goldberg ,  David Schiff

发明人： Steven GOLDBERG ,  Michael Goldberg ,  David Schiff

IPC分类号： A61M5/42

CPC分类号： A61M5/422 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在器械前端上的尖端套管和可移除地安装在突出的光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US20240353176A1

公开(公告)日：2024-10-24

申请号：US18641203

申请日：2024-04-19

申请人： Michael Goldberg

发明人： Michael Goldberg

IPC分类号： F26B25/00 ,  F26B3/04

CPC分类号： F26B25/006 ,  F26B3/04

摘要： Methods, apparatuses, and systems for a closed loop product drying process are disclosed. Heated dry air enters a drying chamber, extracts moisture from a product to be dried, and exits the drying chamber, cooler and wetter. A heat pump air handler dries and warms the air from the drying chamber exhaust, and returns it to the drying chamber, in a closed air loop. The heat pump air handler includes a dehumidifier means in the closed air loop flow path. The dehumidifier means removes entrained moisture from wet air exiting the drying chamber, reheats the air, and returns it to the drying chamber.

公开(公告)号：US08324156B2

公开(公告)日：2012-12-04

申请号：US12546283

申请日：2009-08-24

申请人： Ehud Arbit ,  Michael Goldberg ,  Shingal Majuru

发明人： Ehud Arbit ,  Michael Goldberg ,  Shingal Majuru

IPC分类号： A61K38/28

CPC分类号： A61K38/28 ,  A61B5/14532 ,  A61K31/192 ,  A61K38/00

摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

摘要翻译： 用于治疗哺乳动物葡萄糖耐量异常和早期和晚期糖尿病的方法，用于预防性保护和细胞功能，有助于预防和细胞死亡，预防2型糖尿病哺乳动物的明显糖尿病发作，治疗目前的 包括葡萄糖耐量降低或糖尿病患者的血糖控制功能障碍的水平，包括口服给药胰岛素和促进胰岛素在进食之前或之后的胰岛素从胃肠道吸收的递送剂，例如在摄取前约10分钟内 一顿饭，慢性的。 除了施用快速作用的胰岛素以提供第一胰岛素峰之外，所述方法还包括施用缓慢作用的胰岛素以提供在稍后时间但持续时间更长的时间发生的第二胰岛素峰。 这些方法可以改善血糖控制，没有低血糖，高胰岛素血症和体重增加的风险，以及通常与胰岛素治疗相关的频繁血糖监测的需要。

公开(公告)号：US20120153691A1

公开(公告)日：2012-06-21

申请号：US13404857

申请日：2012-02-24

申请人： Michael Goldberg ,  Ruth Timme

发明人： Michael Goldberg ,  Ruth Timme

IPC分类号： B60N2/28

CPC分类号： B60N2/28 ,  B08B3/02

摘要： A child car seat subframe that is easily disassembled into component sections for washing within a residential-sized dishwasher. The car seat subframe can be disassembled by hand, and each individual component is capable of fitting in a residential-sized dishwasher individually and collectively. The component sections are attached by a combination of registration tabs and slots, and held tightly together by fasteners, or attached by a combination of tongue and groove joints. Hanging devices, such as hooks, may be formed on one side of each component section to facilitate hanging on racks in a dishwasher. The car seat subframe back panel and side panels are disassembled into a plurality of segments for easily fitting in a dishwasher.

摘要翻译： 一个儿童汽车座椅子框架，容易拆卸成部件，用于在住宅大小的洗碗机内进行清洗。 汽车座椅子框架可以手动拆卸，每个单独的部件都可以单独和集体地安装在住宅尺寸的洗碗机中。 组件部分通过配准片和槽的组合连接，并通过紧固件紧紧地保持在一起，或者通过舌和槽接头的组合来附接。 可以在每个部件部分的一侧上形成诸如钩子的悬挂装置，以便于挂在洗碗机中的机架上。 汽车座椅副翼后面板和侧板被分解成多个段，以容易地装配在洗碗机中。

公开(公告)号：US20100223682A1

公开(公告)日：2010-09-02

申请号：US12649489

申请日：2009-12-30

申请人： Yitzhak Katz ,  Michael Goldberg

发明人： Yitzhak Katz ,  Michael Goldberg

IPC分类号： A01K67/00 ,  C07K7/06 ,  C07H21/04 ,  C12N15/63 ,  A61K38/08 ,  G01N33/00

CPC分类号： C07K14/4732 ,  A01K2267/01 ,  A61K38/00

摘要： This invention provides an altered kosher kappa casein polypeptide having at least one altered amino acid in a defined amino acid stretch. The defined amino acid stretch contributes to an allergic reaction induced by a kosher wild-type casein polypeptide in a human subject. Moreover, the defined amino acid stretch is expressed solely in kosher animals. The invention further provides an expression system for expressing the altered kosher casein polypeptide.

摘要翻译： 本发明提供了在限定的氨基酸延伸中具有至少一个改变的氨基酸的改变的犹太人κ酪蛋白多肽。 所定义的氨基酸伸展有助于由人类受试者中的犹太野生型酪蛋白多肽诱导的过敏反应。 此外，定义的氨基酸伸展仅在犹太人动物中表达。 本发明还提供了用于表达改变的乳清酪蛋白多肽的表达系统。