公开(公告)号：US20050182746A1

公开(公告)日：2005-08-18

申请号：US10997687

申请日：2004-11-24

申请人： Steven Potts ,  Sandor Szalma ,  Yin Yu ,  Scott Kahn ,  David Edwards

发明人： Steven Potts ,  Sandor Szalma ,  Yin Yu ,  Scott Kahn ,  David Edwards

IPC分类号： G06F7/00 ,  G06F17/30 ,  G06F19/16 ,  G06F19/28

CPC分类号： G16B50/00 ,  G16B15/00

摘要： Systems and methods for storing protein structure information are provided. The system comprises a non-public database storing protein structure information, wherein the non-public database is coupled to a public database of non-proprietary protein structure information and to non-public sources of proprietary protein structure information. The non-public database may also be coupled to a database having protein structure information for substantially all the proteins of at least one organism genome. The method may comprise loading protein structure data from at least one public database and loading protein structure data from one or more proprietary sources of protein structure information. The public database may comprise the Protein Data Bank (PDB). Certain types of additional information are also advantageously loaded into the database. These may include classification data corresponding to at least one protein ontology. Mass spectroscopy data, NMR data and x-ray crystallography data may also be loaded into the database.

摘要翻译： 提供了存储蛋白质结构信息的系统和方法。 该系统包括存储蛋白质结构信息的非公开数据库，其中非公开数据库耦合到非专有蛋白质结构信息的公共数据库以及专有蛋白质结构信息的非公有源。 非公开数据库还可以耦合到具有至少一个生物基因组的基本上所有蛋白质的蛋白质结构信息的数据库。 该方法可以包括从至少一个公共数据库加载蛋白质结构数据并从蛋白质结构信息的一个或多个专有来源加载蛋白质结构数据。 公共数据库可以包括蛋白质数据库（PDB）。 某些类型的附加信息也有利地被加载到数据库中。 这些可以包括对应于至少一个蛋白质本体的分类数据。 质谱数据，NMR数据和X射线晶体学数据也可以加载到数据库中。

公开(公告)号：US20150004630A1

公开(公告)日：2015-01-01

申请号：US13934237

申请日：2013-07-03

申请人： Holger Lange ,  Josheph Krueger ,  George Young D. ,  Trevor Johnson ,  Frank Voelker ,  Steven Potts

发明人： Holger Lange ,  Josheph Krueger ,  George Young D. ,  Trevor Johnson ,  Frank Voelker ,  Steven Potts

IPC分类号： G01N33/50

CPC分类号： G01N33/5005 ,  G01N15/1463 ,  G01N2015/1006 ,  G01N2035/00138 ,  G06K9/0014 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/30024

摘要： Methods for cell-based tissue analysis utilize modern trends in digital microscopy to obtain, process, calibrate, and analyze digital images of tissue sections to quantify cell-based data for improved histological analysis. Using data from multiple images of a common tissue section, or data from images of multiple tissue sections, additional degrees of freedom are realized and the resulting analysis provides added depth to histological analysis of tissue samples. With computerized analytical methods, speed and accuracy of histological analysis is greatly improved.

摘要翻译： 基于细胞的组织分析的方法利用数字显微镜中的现代趋势来获得，处理，校准和分析组织切片的数字图像，以量化基于细胞的数据以改善组织学分析。 使用来自多个组织部分的多个图像的数据或来自多个组织切片图像的数据，实现了附加的自由度，并且所得到的分析为组织样本的组织学分析提供了附加的深度。 采用电脑化分析方法，大大提高了组织学分析的速度和准确性。

公开(公告)号：US20120076390A1

公开(公告)日：2012-03-29

申请号：US13247991

申请日：2011-09-28

申请人： Steven Potts ,  Trevor Johnson ,  Frank Voelker ,  George Young D

发明人： Steven Potts ,  Trevor Johnson ,  Frank Voelker ,  George Young D

IPC分类号： G06K9/00

CPC分类号： G06T7/0014 ,  G06T7/38 ,  G06T2207/10056 ,  G06T2207/20104 ,  G06T2207/30096

摘要： Feature analysis on consecutive tissue sections (FACTS) includes obtaining a plurality of consecutive tissue sections from a tissue sample, staining the sections with at least one biomarker, obtaining a digital image thereof, and identifying one or more regions of interest within a middle of the consecutive tissue sections. The digital images of the consecutive tissue sections are registered for alignment and the one or more regions of interest are transferred from the image of the middle section to the images of the adjacent sections. Each image of the consecutive tissue sections is then analyzed and scored as appropriate. Using FACTS methods, pathologist time for annotation is reduced to a single slide. Optionally, multiple middle sections may be annotated for regions of interest and transferred accordingly.

摘要翻译： 在连续组织切片（FACTS）上的特征分析包括从组织样本获得多个连续的组织切片，用至少一个生物标志物染色切片，获得其数字图像，以及鉴定所述切片的中间的一个或多个感兴趣区域 连续组织切片。 注册连续组织部分的数字图像以进行对准，并且将一个或多个感兴趣区域从中间部分的图像转移到相邻部分的图像。 然后对连续组织切片的每个图像进行分析并适当评分。 使用FACTS方法，病理学家注释时间缩短到一个幻灯片。 可选地，可以针对感兴趣的区域注释多个中间部分，并相应地传送。

公开(公告)号：US08787651B2

公开(公告)日：2014-07-22

申请号：US13247991

申请日：2011-09-28

申请人： Steven Potts ,  Trevor Johnson ,  Frank Voelker ,  George David Young

发明人： Steven Potts ,  Trevor Johnson ,  Frank Voelker ,  George David Young

IPC分类号： G06K9/00

CPC分类号： G06T7/0014 ,  G06T7/38 ,  G06T2207/10056 ,  G06T2207/20104 ,  G06T2207/30096

摘要： Feature analysis on consecutive tissue sections (FACTS) includes obtaining a plurality of consecutive tissue sections from a tissue sample, staining the sections with at least one biomarker, obtaining a digital image thereof, and identifying one or more regions of interest within a middle of the consecutive tissue sections. The digital images of the consecutive tissue sections are registered for alignment and the one or more regions of interest are transferred from the image of the middle section to the images of the adjacent sections. Each image of the consecutive tissue sections is then analyzed and scored as appropriate. Using FACTS methods, pathologist time for annotation is reduced to a single slide. Optionally, multiple middle sections may be annotated for regions of interest and transferred accordingly.

摘要翻译： 在连续组织切片（FACTS）上的特征分析包括从组织样本获得多个连续的组织切片，用至少一个生物标志物染色切片，获得其数字图像，以及鉴定所述切片的中间的一个或多个感兴趣区域 连续组织切片。 注册连续组织部分的数字图像以进行对准，并且将一个或多个感兴趣区域从中间部分的图像转移到相邻部分的图像。 然后对连续组织切片的每个图像进行分析并适当评分。 使用FACTS方法，病理学家注释时间缩短到一个幻灯片。 可选地，可以针对感兴趣的区域注释多个中间部分，并相应地传送。

公开(公告)号：US20080100076A1

公开(公告)日：2008-05-01

申请号：US11925427

申请日：2007-10-26

申请人： Steven Potts

发明人： Steven Potts

IPC分类号： B60P3/00

CPC分类号： B60R9/06 ,  B62B2203/70

摘要： A cargo carrying system for use with a vehicle. The system includes a platform having roller members on an underside thereof to facilitate movement of the platform along the ground. Also included is a connection assembly which serves to permit the attachment of the platform to a vehicle. In one embodiment, both a first height adjustment mechanism and a separate, finely adjustable height mechanism are included between the connection assembly and the platform. Also included is an intermediate, slidable member used between the platform and connection member to facilitate the connection of the platform to the vehicle.

摘要翻译： 一种用于车辆的货物运输系统。 该系统包括在其下侧具有辊构件的平台，以便于平台沿地面移动。 还包括用于允许平台附接到车辆的连接组件。 在一个实施例中，在连接组件和平台之间包括第一高度调节机构和单独的精细调节的高度机构。 还包括在平台和连接构件之间使用的中间滑动构件，以便于平台与车辆的连接。