公开(公告)号：US20050222011A1

公开(公告)日：2005-10-06

申请号：US10934272

申请日：2004-09-03

申请人： Steven Rosen ,  Christopher Sassetti

发明人： Steven Rosen ,  Christopher Sassetti

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61P29/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C12P21/02 ,  C12P21/08

CPC分类号： C07K16/28 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30

摘要： Podocalyxin like proteins (e.g. PCLP and PCLP-2) having selectin ligand activity are provided. Also provided are nucleic acid compositions encoding novel PCLP-2 proteins. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with podocalyxin like protein activity. In particular, methods of treating diseases associated with podocalyxin like protein selectin binding activity and/or chemokine presenting activity are provided, where such diseases include inflammation and the like.

摘要翻译： 提供了具有选择蛋白配体活性的磷霉素样蛋白（例如PCLP和PCLP-2）。 还提供了编码新型PCLP-2蛋白质的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用，以及用于与足胶质细胞样蛋白活性相关的疾病状况的治疗疗法。 特别地，提供了治疗与足胶质相关疾病如蛋白质选择蛋白结合活性和/或趋化因子呈递活性的方法，其中这些疾病包括炎症等。