公开(公告)号：US20140271463A1

公开(公告)日：2014-09-18

申请号：US14207396

申请日：2014-03-12

Applicant: Stichting VU-VUmc

Inventor： Marta DEL CAMPO MILAN ,  Cornelia Ramona Jimenez ,  Chrlott Elisabeth Teunissen

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K51/1018 ,  A61K51/1027 ,  C07K14/4711 ,  G01N33/56966 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/50

Abstract: The disclosure relates to the use of altered BRI2 levels as a biomarker for the risk of developing Alzheimer's disease. Novel treatments based on altered BRI2 levels and anti-BRI2 antibodies are also provided.

Abstract translation: 本公开涉及使用改变的BRI2水平作为发展阿尔茨海默病的风险的生物标志物。 还提供了基于改变的BRI2水平和抗BRI2抗体的新型治疗。