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1.发明申请POTENT MUCOSAL IMMUNE RESPONSE INDUCED BY MODIFIED IMMUNOMODULATORY OLIGONUCLEOTIDES 审中-公开改性免疫组化寡核苷酸诱导的轻度粘膜免疫应答公开(公告)号：US20110123540A1
公开(公告)日：2011-05-26
申请号：US12952868
申请日：2010-11-23
申请人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
发明人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
IPC分类号： A61K39/395 , A61K39/00 , A61K39/35 , A61K39/39 , A61P37/02
CPC分类号： A61K39/0008 , A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/543 , A61K2039/55561
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers on mucosal innate immunity as well as adjuvant activity using ovalbumin (OVA) as an antigen through administration to the mucosal lining.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫反应物对粘膜先天免疫的治疗用途以及使用卵白蛋白（OVA）作为抗原通过给予粘膜衬里的佐剂活性。
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2.发明申请Potent mucosal immune response induced by modified immunomodulatory oligonucleotides 审中-公开由修饰的免疫调节寡核苷酸诱导的强力粘膜免疫应答公开(公告)号：US20050222072A1
公开(公告)日：2005-10-06
申请号：US11060228
申请日：2005-02-17
申请人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
发明人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
CPC分类号： A61K39/0008 , A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/543 , A61K2039/55561
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers on mucosal innate immunity as well as adjuvant activity using ovalbumin (OVA) as an antigen through administration to the mucosal lining.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫反应物对粘膜先天免疫的治疗用途以及使用卵白蛋白（OVA）作为抗原通过给予粘膜衬里的佐剂活性。
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3.发明授权Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto 有权使用粪便样受体抑制剂预防和治疗高胆固醇血症和高脂血症及其相关疾病公开(公告)号：US08853177B2
公开(公告)日：2014-10-07
申请号：US12574576
申请日：2009-10-06
申请人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
发明人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
CPC分类号： A61K31/4706 , A61K31/7088
摘要： The invention provides the use of TLR inhibitors or a pharmaceutically acceptable derivative thereof, optionally in combination with one or more lipid lowering composition, cholesterol lowering composition, diuretics, non-steroidal anti-inflammatory compounds (NSAIDs), antibodies, antisense oligonucleotides, TLR agonists, TLR antagonists, peptides, proteins or gene therapy vectors or combinations thereof for the prevention or treatment of hypercholesterolemia and/or hyperlipidemia and/or diseases associated therewith.
摘要翻译： 本发明提供TLR抑制剂或其药学上可接受的衍生物的用途，任选地与一种或多种降脂组合物，降胆固醇组合物，利尿剂，非甾体抗炎化合物（NSAID），抗体，反义寡核苷酸，TLR激动剂组合 ，TLR拮抗剂，肽，蛋白质或基因治疗载体或其组合，用于预防或治疗高胆固醇血症和/或高脂血症和/或与之相关的疾病。
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4.发明申请Potentiation of Autoimmune and Inflammatory Disease Treatments by Immune Regulatory Oligonucleotide (IRO) Antagonists of TLR7 and TLR9 有权TLR7和TLR9的免疫调节寡核苷酸（IRO）拮抗剂对自身免疫和炎症疾病治疗的增强公开(公告)号：US20110171209A1
公开(公告)日：2011-07-14
申请号：US12791636
申请日：2010-06-01
申请人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
发明人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K39/00 , A61K38/16 , A61P37/06
CPC分类号： C12N15/117 , A61K31/7088 , A61K38/1793 , A61K45/06 , A61K2300/00 , C12N2310/17 , C12N2310/3183 , C12N2310/319 , C12N2310/321 , C12N2310/332 , C12N2310/336 , C12N2310/3521 , C12N2310/51 , C12N2320/31 , Y02A50/463
摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs and potentiators of anti-inflammatory agents that inhibit TNF for the prevention and treatment of inflammatory and autoimmune diseases.
摘要翻译： 本发明提供了免疫调节寡核苷酸（IRO）作为TLR的拮抗剂和抗炎剂的增强剂的用途，其抑制TNF用于预防和治疗炎性和自身免疫性疾病。
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5.发明授权Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9 有权TLR7和TLR9的免疫调节寡核苷酸（IRO）拮抗剂对自身免疫和炎性疾病治疗的加强公开(公告)号：US08987221B2
公开(公告)日：2015-03-24
申请号：US12791636
申请日：2010-06-01
申请人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
发明人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
IPC分类号： A61K48/00 , C12N15/11 , A61K31/7088 , A61K38/17 , A61K45/06 , C12N15/117
CPC分类号： C12N15/117 , A61K31/7088 , A61K38/1793 , A61K45/06 , A61K2300/00 , C12N2310/17 , C12N2310/3183 , C12N2310/319 , C12N2310/321 , C12N2310/332 , C12N2310/336 , C12N2310/3521 , C12N2310/51 , C12N2320/31 , Y02A50/463
摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs and potentiators of anti-inflammatory agents that inhibit TNF for the prevention and treatment of inflammatory and autoimmune diseases.
摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR的拮抗剂和抗炎剂的增强剂的用途，所述抗炎药抑制TNF用于预防和治疗炎性和自身免疫性疾病。
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6.发明申请Modulation of immunostimulatory properties by small oligonucleotide-based compounds 失效通过小寡核苷酸类化合物调节免疫刺激性质公开(公告)号：US20050130918A1
公开(公告)日：2005-06-16
申请号：US10852598
申请日：2004-05-24
申请人： Sudhir Agrawal , Ekambar Kandimalla , Fu-Gang Zhu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Fu-Gang Zhu
CPC分类号： C12N15/117 , A61K39/39 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/32 , C12N2310/33 , C12N2310/336 , C12N2310/52
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫
性。 本发明的免疫体包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核苷酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5'端。-
7.发明申请Use of Inhibitors of Toll-Like Receptors in the Prevention and Treatment of Hypercholesterolemia and Hyperlipidemia and Diseases Related Thereto 有权使用Toll样受体抑制剂预防和治疗高胆固醇血症和高脂血症及其相关疾病公开(公告)号：US20100098685A1
公开(公告)日：2010-04-22
申请号：US12574576
申请日：2009-10-06
申请人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
发明人： Fu-Gang Zhu , Ekambar Kandimalla , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K31/711 , A61K39/00 , A61K31/4706 , A61K31/7088 , A61K38/45 , A61K38/02 , A61P9/10
CPC分类号： A61K31/4706 , A61K31/7088
摘要： The invention provides the use of TLR inhibitors or a pharmaceutically acceptable derivative thereof, optionally in combination with one or more lipid lowering composition, cholesterol lowering composition, diuretics, non-steroidal anti-inflammatory compounds (NSAIDs), antibodies, antisense oligonucleotides, TLR agonists, TLR antagonists, peptides, proteins or gene therapy vectors or combinations thereof for the prevention or treatment of hypercholesterolemia and/or hyperlipidemia and/or diseases associated therewith.
摘要翻译： 本发明提供TLR抑制剂或其药学上可接受的衍生物的用途，任选地与一种或多种降脂组合物，降胆固醇组合物，利尿剂，非甾体抗炎化合物（NSAID），抗体，反义寡核苷酸，TLR激动剂组合 ，TLR拮抗剂，肽，蛋白质或基因治疗载体或其组合，用于预防或治疗高胆固醇血症和/或高脂血症和/或与之相关的疾病。
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公开(公告)号：US20100166805A1
公开(公告)日：2010-07-01
申请号：US12592850
申请日：2009-12-03
申请人： Sudhir Agrawal , Fu-Gang Zhu , Ekambar Kandimalla
发明人： Sudhir Agrawal , Fu-Gang Zhu , Ekambar Kandimalla
IPC分类号： A61K39/00 , A61K31/7088 , A61K38/02 , A61K38/16 , A61P11/00
CPC分类号： C12N15/117 , A61K39/39 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/32 , C12N2310/33 , C12N2310/336 , C12N2310/52
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
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9.发明授权Modulation of immunostimulatory properties by small oligonucleotide-based compounds 失效通过小寡核苷酸类化合物调节免疫刺激性质公开(公告)号：US07713535B2
公开(公告)日：2010-05-11
申请号：US10852598
申请日：2004-05-24
IPC分类号： A61K45/00
CPC分类号： C12N15/117 , A61K39/39 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/32 , C12N2310/33 , C12N2310/336 , C12N2310/52
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫
性。 本发明的免疫体包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核苷酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5'端。
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