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![3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use of thereof](/abs-image/US/2007/05/17/US20070112003A1/abs.jpg.150x150.jpg)
1.发明申请3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use of thereof 失效3,5-二取代 - [1,2,4] - 恶二唑和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其使用公开(公告)号：US20070112003A1
公开(公告)日：2007-05-17
申请号：US11593030
申请日：2006-11-06
申请人： Sui Cai , Han-Zhong Zhang , Jared Kuemmerle , Hong Zhang , William Kemnitzer
发明人： Sui Cai , Han-Zhong Zhang , Jared Kuemmerle , Hong Zhang , William Kemnitzer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4245 , C07D413/14
CPC分类号： A61K31/4245 , A61K31/4439
摘要： Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了由式I表示的3,5-二取代 - [1,2,4] - 恶二唑及其类似物：其中Ar 1，R 2，A， B和D在本文中定义。 本发明涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。
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![Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2006/05/18/US20060104998A1/abs.jpg.150x150.jpg)
2.发明申请Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效取代的4-芳基-4H-吡咯并[2,3-h]色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US20060104998A1
公开(公告)日：2006-05-18
申请号：US10514427
申请日：2003-05-16
申请人： Sui Cai , Songchun Jiang , William Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
发明人： Sui Cai , Songchun Jiang , William Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
IPC分类号： A61K31/724 , A61K31/498 , A61K31/497 , A61K31/4439 , A61K31/407 , C07D491/02
CPC分类号： C07D491/04
摘要： The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由式（I）表示的取代的4H-色烯及其类似物：其中R 1，R 3，R 5， SUP，A，D，Y和Z在本文中定义。 本发明还涉及具有式（I）的化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
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3.发明申请Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效取代的香豆素和喹啉和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US20050090526A1
公开(公告)日：2005-04-28
申请号：US10989057
申请日：2004-11-16
申请人： Sui Cai , Hong Zhang , William Kemnitzer , Songchun Jiang , John Drewe , Richard Storer
发明人： Sui Cai , Hong Zhang , William Kemnitzer , Songchun Jiang , John Drewe , Richard Storer
IPC分类号： A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D335/06 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/366 , A61K31/382
CPC分类号： C07D335/06 , A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由通式I表示的取代香豆素和喹啉及其类似物：其中A，B，X，Y和Z如本文所定义。 本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
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4.发明申请公开(公告)号：US20080300191A1
公开(公告)日：2008-12-04
申请号：US10839753
申请日：2004-05-06
CPC分类号： C07K5/06043 , A61K38/00 , C07K5/06026 , C07K5/06052 , C07K5/06086 , C07K5/06095 , C07K5/06191 , Y02A50/463 , Y02A50/465
摘要： Disclosed are protease inhibitors for coronaviruses and SARS-CoV, or picornaviruses, and the use of these protease inhibitors for preventing, reducing, ameliorating and treating a disease or condition caused by coronaviruses and SARS-CoV, or picornaviruses. Also disclosed are methods of reducing or preventing the spread of coronavirus, or picornaviruses, and preventing or reducing the replication of coronavirus, or picornaviruses, with the compounds of the present invention
摘要翻译： 公开了用于冠状病毒和SARS-CoV或微小核糖核酸病毒的蛋白酶抑制剂，以及这些蛋白酶抑制剂用于预防，减少，改善和治疗由冠状病毒和SARS-CoV或小核糖核酸病毒引起的疾病或病症的用途。 还公开了减少或预防冠状病毒或小核糖核酸病毒的扩散以及预防或减少冠状病毒或小核糖核酸病毒与本发明化合物复制的方法
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5.发明授权Protease inhibitors for coronaviruses and SARS-CoV and the use thereof 失效用于冠状病毒和SARS-CoV的蛋白酶抑制剂及其用途公开(公告)号：US07504382B2
公开(公告)日：2009-03-17
申请号：US10839753
申请日：2004-05-06
IPC分类号： A61K38/00
CPC分类号： C07K5/06043 , A61K38/00 , C07K5/06026 , C07K5/06052 , C07K5/06086 , C07K5/06095 , C07K5/06191 , Y02A50/463 , Y02A50/465
摘要： Disclosed are protease inhibitors for coronaviruses and SARS-CoV, or picornaviruses, and the use of these protease inhibitors for preventing, reducing, ameliorating and treating a disease or condition caused by coronaviruses and SARS-CoV, or picornaviruses. Also disclosed are methods of reducing or preventing the spread of coronavirus, or picornaviruses, and preventing or reducing the replication of coronavirus, or picornaviruses, with the compounds of the present invention.
摘要翻译： 公开了用于冠状病毒和SARS-CoV或微小核糖核酸病毒的蛋白酶抑制剂，以及这些蛋白酶抑制剂用于预防，减少，改善和治疗由冠状病毒和SARS-CoV或小核糖核酸病毒引起的疾病或病症的用途。 还公开了减少或预防冠状病毒或小核糖核酸病毒的扩散以及用本发明化合物预防或减少冠状病毒或小核糖核酸病毒复制的方法。
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![3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2006/12/05/US07144876B2/abs.jpg.150x150.jpg)
6.发明授权3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效3,5-二取代 - [1,2,4] - 恶二唑和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US07144876B2
公开(公告)日：2006-12-05
申请号：US10737865
申请日：2003-12-18
IPC分类号： A61K31/56 , C07D471/00 , C07D271/06 , C07D233/38
CPC分类号： A61K31/4245 , A61K31/4439
摘要： Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了由式I表示的3,5-二取代 - [1,2,4] - 恶二唑及其类似物：其中Ar 1，R 2，A， B和D在本文中定义。 本发明涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。
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![3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2008/01/08/US07317029B2/abs.jpg.150x150.jpg)
7.发明授权3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效3,5-二取代 - [1,2,4] - 恶二唑和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US07317029B2
公开(公告)日：2008-01-08
申请号：US11593030
申请日：2006-11-06
IPC分类号： A61K31/41 , C07D271/06
CPC分类号： A61K31/4245 , A61K31/4439
摘要： Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了由式I表示的3,5-二取代 - [1,2,4] - 恶二唑及其类似物：其中Ar 1，R 2，A， B和D在本文中定义。 本发明涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。
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公开(公告)号：US20070249601A1
公开(公告)日：2007-10-25
申请号：US11693432
申请日：2007-03-29
申请人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
发明人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
IPC分类号： A61K31/47 , A61K31/50 , A61K31/517 , A61K31/52 , A61K31/535 , A61P31/00
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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公开(公告)号：US20070244113A1
公开(公告)日：2007-10-18
申请号：US11680843
申请日：2007-03-01
申请人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
发明人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
IPC分类号： A61K31/517 , A61K31/5355 , C07D239/94 , C07D401/12 , C07D413/12 , C07D473/00
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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公开(公告)号：US20070208044A1
公开(公告)日：2007-09-06
申请号：US11620498
申请日：2007-01-05
申请人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
发明人： Sui Cai , Nilantha Sirisoma , Azra Pervin , John Drewe , Shailaja Kasibhatla , Songchun Jiang , Hong Zhang , Chris Pleiman , Vijay Baichwal , John Manfredi , Leena Bhoite
IPC分类号： A61K31/517 , C07D403/02 , C07D239/94
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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