公开(公告)号：US09155697B2

公开(公告)日：2015-10-13

申请号：US12444961

申请日：2007-10-09

申请人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

发明人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

IPC分类号： A61K38/18 ,  C07K14/485 ,  A61K9/00 ,  A61K47/10

CPC分类号： A61K9/006 ,  A61K38/1808 ,  A61K47/10 ,  C07K14/485

摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.

摘要翻译： 本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。 液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。 因此，液体组合物可以长期储存和分配。 稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。

公开(公告)号：US20100035809A1

公开(公告)日：2010-02-11

申请号：US12444961

申请日：2007-10-09

申请人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

发明人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

IPC分类号： A61K38/18

CPC分类号： A61K9/006 ,  A61K38/1808 ,  A61K47/10 ,  C07K14/485

摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.

摘要翻译： 本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。 液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。 因此，液体组合物可以长期储存和分配。 稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。