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    Reverse-turn mimetics and method relating thereto
    2.
    发明申请
    Reverse-turn mimetics and method relating thereto 有权

    公开(公告)号：US20070021431A1

    公开(公告)日：2007-01-25

    申请号：US10803179

    申请日：2004-03-17

    申请人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    发明人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    IPC分类号： A61K31/498 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    Reverse-turn mimetics and method relating thereto
    3.
    发明申请
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号：US20070021425A1

    公开(公告)日：2007-01-25

    申请号：US10826972

    申请日：2004-04-16

    申请人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    发明人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    IPC分类号： A61K31/53 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/4985 ,  Y02A50/467

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

    Reverse-turn mimetics and method relating thereto
    4.
    发明申请
    Reverse-turn mimetics and method relating thereto 有权

    公开(公告)号：US20060084655A1

    公开(公告)日：2006-04-20

    申请号：US11242653

    申请日：2005-10-04

    申请人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    发明人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

    IPC分类号： A61K31/498 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
    6.
    发明申请
    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
    反向转换和相关的方法

    公开(公告)号：US20100081655A1

    公开(公告)日：2010-04-01

    申请号：US12541388

    申请日：2009-08-14

    申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    IPC分类号： A61K31/53 ,  C07D487/04 ,  A61K31/538 ,  A61K31/5377

    CPC分类号： C07D487/04 ,  A61K31/4985 ,  Y02A50/467

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

    Reverse-turn mimetics and method relating thereto
    8.
    发明授权
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号：US08729262B2

    公开(公告)日：2014-05-20

    申请号：US13172315

    申请日：2011-06-29

    申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P19/02 ,  A61P35/00

    CPC分类号： C07D487/04 ,  A61K31/4985 ,  Y02A50/467

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

    Reverse-turn mimetics and method relating thereto
    9.
    发明授权
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号：US08106049B2

    公开(公告)日：2012-01-31

    申请号：US12553858

    申请日：2009-09-03

    申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    IPC分类号： C07D487/04 ,  A61K31/53

    CPC分类号： C07D487/04

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility as diagnostic and therapeutic agents for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis. In one embodiment, these reverse-term mimetics have a general structure of formula (VI): wherein Ra, Rb, Rc, X1, X2 and X3 are defined as provided herein.

    摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构具有用作抑制或治疗由Wnt信号传导途径调节的疾病，如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病相关的再狭窄的诊断和治疗剂的效用， 结节性硬化综合征，阿尔茨海默氏病，过度毛发生长或丧失或溃疡性结肠炎。 在一个实施方案中，这些反相模拟物具有式（VI）的通式结构：其中R a，R b，R c，X 1，X 2和X 3如本文所提供。

    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
    10.
    发明申请
    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
    反向转换和相关的方法

    公开(公告)号：US20110294797A1

    公开(公告)日：2011-12-01

    申请号：US13194428

    申请日：2011-07-29

    申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    IPC分类号： A61K31/538 ,  A61K31/53 ,  A61P17/14 ,  A61P35/00 ,  A61P19/02 ,  A61P25/28 ,  C07D487/04 ,  A61K31/5377

    CPC分类号： C07D487/04

    摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。