Reverse-turn mimetics and method relating thereto

    公开(公告)号:US20070021431A1

    公开(公告)日:2007-01-25

    申请号:US10803179

    申请日:2004-03-17

    IPC分类号: A61K31/498 C07D487/04

    CPC分类号: C07D487/04

    摘要: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    Reverse-turn mimetics and method relating thereto
    3.
    发明申请
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号:US20070021425A1

    公开(公告)日:2007-01-25

    申请号:US10826972

    申请日:2004-04-16

    IPC分类号: A61K31/53 C07D487/04

    摘要: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译: 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性,包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病,例如癌症,特别是结肠直肠癌,与血管成形术,多囊肾病,异常血管生成疾病,类风湿性关节炎疾病,结节性硬化综合征相关的再狭窄 ,阿尔茨海默氏病,过度毛发生长或损失,或溃疡性结肠炎。

    Reverse-turn mimetics and method relating thereto

    公开(公告)号:US20060084655A1

    公开(公告)日:2006-04-20

    申请号:US11242653

    申请日:2005-10-04

    IPC分类号: A61K31/498 C07D487/04

    CPC分类号: C07D487/04

    摘要: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    MOBILIZED LAUNDRY SERVICE SYSTEM
    6.
    发明申请

    公开(公告)号:US20170098191A1

    公开(公告)日:2017-04-06

    申请号:US15047168

    申请日:2016-02-18

    IPC分类号: G06Q10/08 B60P9/00 G06Q10/10

    摘要: A distributed laundry system having mobilized laundry vehicles, including true laundry conveyors in the vehicles, and including a specialized distributed computer network in the vehicles to handle the circumstances of mobile laundry operations, such as special laundry instructions. In addition, procedures and operations which allow the vehicles to cooperate to provide efficient pickup and drop off services at locations of the customers' choices (such as at home or work), including flexible territories for the trucks, customer user interfaces on mobile devices such as cell phones, mobile computing devices and the like, and precise time estimates of pick-up and drop-off times.

    Vented baby bottle
    7.
    发明授权
    Vented baby bottle 有权
    通风婴儿奶瓶

    公开(公告)号:US08931650B2

    公开(公告)日:2015-01-13

    申请号:US12030629

    申请日:2008-02-13

    IPC分类号: A61J11/02 A61J9/04 A61J1/20

    摘要: Baby bottles can have a single container, or two containers to create a space for thermal isolation, as selected by the user. The baby bottle can be vented to allow air to enter the bottle through a passageway as liquid is removed. A filter and one-way valve can be provided in the passageway. The passageway can be formed by radially aligning a vent opening in a top cap with a vent opening in a nipple flange, or by providing a channel in the top cap which is always in radial alignment with both the top cap vent opening and the flange vent opening.

    摘要翻译: 婴儿奶瓶可以具有单个容器或两个容器,以便由用户选择的热隔离空间。 当除去液体时,可以将婴儿奶瓶排空,以允许空气通过通道进入瓶子。 通道中可以设置过滤器和单向阀。 通道可以通过将顶盖中的通气口与乳头法兰中的通气口径向对准,或者通过在顶盖中设置通道,以形成通道,该通道总是与顶盖通气口和法兰通气口 开放

    INSTALLATION FIXTURE FOR ELASTOMER BANDS AND METHODS OF USING THE SAME
    8.
    发明申请
    INSTALLATION FIXTURE FOR ELASTOMER BANDS AND METHODS OF USING THE SAME 有权
    弹性体的安装方式及其使用方法

    公开(公告)号:US20130117986A1

    公开(公告)日:2013-05-16

    申请号:US13293972

    申请日:2011-11-10

    IPC分类号: B23P11/00 B23P19/00

    摘要: A kit comprising an installation fixture, a plurality of mechanical fasteners and an embedding tool is provided which allows for an elastomer band to be disposed in a mounting groove around a semiconductor substrate support in a manner that relieves the internal stresses of the elastomer band, leading to an elastomer band with a longer operational lifetime. The installation fixture is secured to a substrate support with mechanical fasteners. An elastomer band is placed around an outer circumference of the installation fixture and rotated back and forth to relieve internal stresses of the elastomer band. The fixture is inverted and the elastomer band is slid vertically off the fixture and into the mounting groove. An embedding tool can be used to completely insert the elastomer band into the mounting groove.

    摘要翻译: 提供一种包括安装夹具,多个机械紧固件和嵌入工具的套件,其允许弹性体带以减轻弹性体带的内部应力的方式设置在半导体衬底支撑件周围的安装槽中,引导 到具有更长使用寿命的弹性体带。 安装夹具用机械紧固件固定到基板支架上。 弹性体带围绕安装夹具的外周放置并且来回旋转以减轻弹性体带的内应力。 夹具被倒置,弹性体带从夹具垂直滑入安装槽。 可以使用嵌入工具将弹性体带完全插入到安装槽中。

    Method and System for Device Integrity Authentication
    9.
    发明申请
    Method and System for Device Integrity Authentication 有权
    设备完整性认证方法与系统

    公开(公告)号:US20120047550A1

    公开(公告)日:2012-02-23

    申请号:US12860247

    申请日:2010-08-20

    IPC分类号: G06F21/00

    摘要: A networked device performs integrity authentication by determining, using a processor, a measured integrity value of the device. The measured integrity value is compared by the processor to an embedded integrity value of the device. Application of a policy to the device is facilitated by the processor based on the comparison.

    摘要翻译: 联网设备通过使用处理器确定设备的测量完整性值来执行完整性认证。 测量的完整性值由处理器与设备的嵌入式完整性值进行比较。 基于比较的处理器便于对设备应用策略。

    Method and Apparatus for Identity Verification
    10.
    发明申请
    Method and Apparatus for Identity Verification 有权
    用于身份验证的方法和装置

    公开(公告)号:US20090235068A1

    公开(公告)日:2009-09-17

    申请号:US12048096

    申请日:2008-03-13

    IPC分类号: H04L9/32

    摘要: A method for identity verification includes receiving a request for proof of identity from a service provider and receiving biometric information associated with a user of a communication device. The method also includes determining that the received biometric information matches a biometric profile that contains biometric information associated with a registered user of the communication device. The method also includes unlocking a private key associated with the registered user in response to determining that the received biometric information matches a biometric profile and sending a request for a digital certificate that is signed with the private key associated with the registered user. The method further includes receiving the digital certificate that includes a public key associated with the registered user and satisfies the request for proof of identity. The method also includes with forwarding the digital certificate to the service provider.

    摘要翻译: 用于身份验证的方法包括从服务提供商接收身份证明请求并接收与通信设备的用户相关联的生物特征信息。 该方法还包括确定所接收的生物特征信息与包含与通信设备的注册用户相关联的生物特征信息的生物特征信息匹配。 该方法还包括响应于确定所接收的生物测定信息与生物特征谱匹配并且发送用与注册用户相关联的私钥签名的数字证书的请求来解锁与注册用户相关联的私钥。 该方法还包括接收包括与注册用户相关联的公钥的数字证书,并且满足身份证明请求。 该方法还包括将数字证书转发到服务提供商。