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    COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE
    4.
    发明申请
    COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
    用于治疗包含长效胰岛素结合剂和长效胰岛素诱导性糖尿病的糖尿病的组合物

    公开(公告)号：US20140120120A1

    公开(公告)日：2014-05-01

    申请号：US14123355

    申请日：2012-06-01

    申请人： Young Eun Woo ,  Myung Hyun Jang ,  Young Jin Park ,  Young Kyung Park ,  Chang Ki Lim ,  Se Chang Kwon

    发明人： Young Eun Woo ,  Myung Hyun Jang ,  Young Jin Park ,  Young Kyung Park ,  Chang Ki Lim ,  Se Chang Kwon

    IPC分类号： A61K47/48 ,  A61K38/26 ,  A61K38/28

    CPC分类号： A61K38/26 ,  A61K38/28 ,  A61K47/68 ,  A61K47/6811 ,  A61K47/6883

    摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.

    摘要翻译： 本发明涉及一种用于预防或治疗糖尿病的组合物，其包含长效胰岛素缀合物和长效促胰岛素肽缀合物，以及用于治疗糖尿病的治疗方法，更具体地说， 作用胰岛素结合物和长效促胰岛素肽结合物抑制胰岛素治疗引起的体重增加，以及由促胰岛素肽治疗引起的呕吐和恶心，并减少所需的胰岛素剂量，从而显着提高药物依从性。 此外，本发明的长效胰岛素缀合物和长效促胰岛素肽缀合物中的每一种都是通过非肽基连接体将胰岛素或促胰岛素肽与免疫球蛋白Fc区连接而制备的，从而显示出改善的体内持续时间 功效和稳定性。

    NON-PEPTIDYL POLYMER-INSULIN MULTIMER AND METHOD FOR PRODUCING THE SAME
    7.
    发明申请
    NON-PEPTIDYL POLYMER-INSULIN MULTIMER AND METHOD FOR PRODUCING THE SAME 有权
    非肽聚合物 - 胰岛素多元及其生产方法

    公开(公告)号：US20140107023A1

    公开(公告)日：2014-04-17

    申请号：US14123258

    申请日：2012-06-01

    申请人： Sung In Lim ,  Myung Hyun Jang ,  Dae Jin Kim ,  Sung Youb Jung ,  Se Chang Kwon

    发明人： Sung In Lim ,  Myung Hyun Jang ,  Dae Jin Kim ,  Sung Youb Jung ,  Se Chang Kwon

    IPC分类号： C07K14/62

    CPC分类号： C07K14/62 ,  A61K38/28 ,  A61K47/52 ,  A61K47/60 ,  A61K47/6921

    摘要： The present invention relates to a non-peptidyl polymer-insulin multimer comprising two or more of a non-peptidyl polymer-insulin conjugate prepared by linking a non-peptidyl polymer and insulin via a covalent bond, in which the conjugates are complexed with cobalt ion to form a multimer, a method and kit for the preparation of the multimer, a pharmaceutical composition for the prevention or treatment of diabetes comprising the multimer as an active ingredient, and a method for preventing or treating diabetes by administering the composition to a subject.

    摘要翻译： 本发明涉及一种非肽基聚合物 - 胰岛素多聚体，其包含通过共价键连接非肽基聚合物和胰岛素而制备的两种或多种非肽基聚合物 - 胰岛素结合物，其中缀合物与钴离子络合 以形成多聚体的制备方法和试剂盒，用于预防或治疗糖尿病的药物组合物，其包含多聚体作为活性成分，以及通过向受试者施用该组合物来预防或治疗糖尿病的方法。