公开(公告)号：US09534040B2

公开(公告)日：2017-01-03

申请号：US14453149

申请日：2014-08-06

申请人： Sungkyunkwan University Foundation for Corporate Collaboration ,  Ajou University Industry-Academic Cooperation Foundation ,  Invitroplant Co., Ltd. ,  Ministry of Agriculture Food and Rural Affairs Animal and Plant Quarantine Agency

发明人： Suk-Chan Lee ,  Yong-Sung Kim ,  Myung-Hee Kwon ,  Tai-Hyun Kim ,  Jeong-Sun Kim ,  Gun-Sup Lee ,  Hye-Kyung Shim ,  Eul-Yong Park ,  Yu-Chul Chung ,  Ki-Yoon Kim ,  Yi-Jung Jung ,  Woo-Ram Lee ,  Young-Rim Kim ,  Jong-Nam Sohn ,  Seung-Hyun Lee ,  Jae Young Song ,  Eun Jin Choi

IPC分类号： C07K16/10 ,  C07K16/44 ,  C07K14/47 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K2039/505 ,  A61K2300/00 ,  C07K14/47 ,  C07K16/44 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity to the animal cell itself. Also provided is an antiviral animal cell containing the protein according to the present invention, or the nucleic acid sequence encoding the protein. The antiviral agent and antiviral animal cell exhibit advantageous effects in that they selectively degrade foreign nucleic acid chains invaded in an animal cell and have no cytotoxicity to the animal cell, thus causing no death of the animal cell.

摘要翻译： 提供了抗动物病毒的抗病毒剂。 抗病毒剂含有蛋白质或编码作为活性成分的蛋白质的蛋白质或核酸序列，该蛋白质具有与动物细胞侵入的外源核酸链具有结合能力和降解能力，并且对动物细胞本身没有细胞毒性。 还提供含有本发明蛋白质或编码该蛋白质的核酸序列的抗病毒动物细胞。 抗病毒剂和抗病毒动物细胞表现出有利的作用，因为它们选择性降解在动物细胞中侵入的外来核酸链，并且对动物细胞没有细胞毒性，因此不会导致动物细胞的死亡。

公开(公告)号：US20160083455A1

公开(公告)日：2016-03-24

申请号：US14453149

申请日：2014-08-06

申请人： Sungkyunkwan University Foundation for Corporate Collaboration ,  Ajou University Industry-Academic Cooperation Foundation ,  Invitroplant Co., Ltd. ,  Ministry of Food, Agriculture, Forestry and Fisheries, National Veterinary Research & Quaranti

发明人： Suk-Chan Lee ,  Yong-Sung Kim ,  Myung-Hee Kwon ,  Tai-Hyun Kim ,  Jeong-Sun Kim ,  Gun-Sup Lee ,  Hye-Kyung Shim ,  Eul-Yong Park ,  Yu-Chul Jung ,  Ki-Yoon Kim ,  Yi-Jung Jung ,  Woo-Ram Lee ,  Young-Rim Kim ,  Jong-Nam Sohn ,  Seung-Hyun Lee ,  Jae Young Song ,  Eun Jin Choi

IPC分类号： C07K16/10

CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K2039/505 ,  A61K2300/00 ,  C07K14/47 ,  C07K16/44 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： Disclosed herein is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity to the animal cell itself. Disclosed herein is further an antiviral animal cell containing the protein according to the present invention, or the nucleic acid sequence encoding the protein. The antiviral agent and antiviral animal cell exhibit advantageous effects in that they selectively degrade foreign nucleic acid chains invaded in an animal cell and have no cytotoxicity to the animal cell, thus causing no death of the animal cell.

摘要翻译： 本文公开了抗动物病毒的抗病毒剂。 抗病毒剂含有蛋白质或编码作为活性成分的蛋白质的蛋白质或核酸序列，该蛋白质具有与动物细胞侵入的外源核酸链具有结合能力和降解能力，并且对动物细胞本身没有细胞毒性。 本文公开了另外含有本发明蛋白质的抗病毒动物细胞或编码该蛋白质的核酸序列。 抗病毒剂和抗病毒动物细胞表现出有利的作用，因为它们选择性降解在动物细胞中侵入的外来核酸链，并且对动物细胞没有细胞毒性，因此不会导致动物细胞的死亡。