Bis pyrazole-1H-pyrazole intermediates and their synthesis
    2.
    发明授权
    Bis pyrazole-1H-pyrazole intermediates and their synthesis 有权
    双吡唑-1H-吡唑中间体及其合成

    公开(公告)号:US06492529B1

    公开(公告)日:2002-12-10

    申请号:US10067492

    申请日:2002-02-05

    IPC分类号: C07D23138

    摘要: Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: wherein Alk, Rx and Rz are described herein.

    摘要翻译: 公开了式(I)的芳族杂环化合物,其中Ar1,Ar2,L,Q和X如本文所述,以及可用于制备此类化合物的中间体化合物。 该化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物,例如慢性炎性疾病。还公开了制备式(I)化合物,其中间体和制备此类中间体的方法的方法,包括双吡唑-1H- 式中的Alk,Rx和Rz的吡唑中间体如本文所述。

    Synthesis for heteroarylamine compounds
    7.
    发明授权
    Synthesis for heteroarylamine compounds 有权
    杂芳基胺化合物的合成

    公开(公告)号:US06603000B2

    公开(公告)日:2003-08-05

    申请号:US09902085

    申请日:2001-07-11

    IPC分类号: C07D41300

    CPC分类号: C07D213/38

    摘要: Disclosed is a novel method of producing heteroaryl amines of the formula(I): wherein X, Y and Z are described herein, the heteroarylamines are useful in the production of heteroaryl ureas which are key component in pharmaceutically active compounds possessing a heteroaryl urea group.

    摘要翻译: 公开了一种制备式(I)的杂芳基胺的新方法:其中X,Y和Z在本文中描述,杂芳基胺可用于制备作为具有杂芳基脲基团的药物活性化合物的关键组分的杂芳基脲。