公开(公告)号：USPP12426P2

公开(公告)日：2002-02-26

申请号：US09145546

申请日：1998-09-02

申请人： Sushil Kumar ,  Nirmal Kumar Patra ,  Hemendra Pratap Singh ,  Alok Kalra ,  Harikesh Bahadur Singh ,  Paltoo Ram ,  Ved Ram Singh ,  Nareshwar Mengi ,  Vijay Pal Singh ,  Muni Ram ,  Ram Sajivan Shukla ,  Kambod Singh ,  Aparbal Singh ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Arif Ali Naqvi ,  Birendra Kumar ,  Man Singh ,  Dharmendra Kumar Rajput ,  Raja Ram ,  Jitendra Pal Singh ,  Vijay Kumar ,  Hasan Tanveer ,  Sheo Ram Sharma

发明人： Sushil Kumar ,  Nirmal Kumar Patra ,  Hemendra Pratap Singh ,  Alok Kalra ,  Harikesh Bahadur Singh ,  Paltoo Ram ,  Ved Ram Singh ,  Nareshwar Mengi ,  Vijay Pal Singh ,  Muni Ram ,  Ram Sajivan Shukla ,  Kambod Singh ,  Aparbal Singh ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Arif Ali Naqvi ,  Birendra Kumar ,  Man Singh ,  Dharmendra Kumar Rajput ,  Raja Ram ,  Jitendra Pal Singh ,  Vijay Kumar ,  Hasan Tanveer ,  Sheo Ram Sharma

IPC分类号： A01H500

CPC分类号： A01H5/02

摘要： A novel mint plant ‘Kosi’ characterized by its high menthol content, high biomass and high oil yield with symmetrical branching giving globular shape to the canopy for equal distribution of sunlight to the lower leaves.

摘要翻译： 一种新颖的薄荷植物“Kosi”，其特征在于其高薄荷醇含量，高生物量和高产油率，具有对称支化，赋予冠层以球体形状，使阳光均匀分布于下叶。

公开(公告)号：US07987700B2

公开(公告)日：2011-08-02

申请号：US12226343

申请日：2007-04-17

申请人： Man Singh

发明人： Man Singh

IPC分类号： G01N11/00 ,  G01N13/00 ,  G01N13/04

CPC分类号： G01N13/04

摘要： The present invention provides an apparatus (Oscosurvismeter) for measuring osmotic pressure, surface tension, viscosity and conductance. Oscosurvismeter is made of Borosil glass material for measuring osmotic pressure, specific conductance, viscosity and surface tension of solutions. Solutions of different strengths are taken in two cells/compartments, partitioned by semi permeable membrane (SPM), respectively. Concentration gradient makes the solvent move towards concentrated solution to establish equilibrium that measures osmotic pressure. The Oscosurvismeter saves time and material, and enhances accuracy and precision in measurements, the instrument consists of six parts: Survismeter, Osmometer, Electrode, Metallic clamp, Semipermeable membrane (SPM), and High Potential metallic springs. The high accuracies data are noted with the instrument.

摘要翻译： 本发明提供一种用于测量渗透压，表面张力，粘度和电导的装置（振荡器）。 振荡器由Borosil玻璃材料制成，用于测量溶液的渗透压，比电导率，粘度和表面张力。 在两个细胞/隔室中分别采用半透膜（SPM）分隔不同强度的溶液。 浓度梯度使溶剂向浓缩溶液移动，建立衡量渗透压的平衡。 Oscosurvismeter可以节省时间和材料，提高测量精度和精度，仪器由六个部分组成：存储器，渗透计，电极，金属夹，半透膜（SPM）和高电位金属弹簧。 仪器注意到高精度数据。

公开(公告)号：US20070260737A1

公开(公告)日：2007-11-08

申请号：US11408184

申请日：2006-04-21

申请人： Jose Gomes ,  Paolina Centonze ,  Sai Zeng ,  Man Singh ,  Ioana Boier-Martin ,  Laurent Balmelli

发明人： Jose Gomes ,  Paolina Centonze ,  Sai Zeng ,  Man Singh ,  Ioana Boier-Martin ,  Laurent Balmelli

IPC分类号： G06F15/16

CPC分类号： G06F8/24 ,  G06F9/451

摘要： A computer-implemented method (and structure) for creating a service client for a service and a role includes exercising an application programming interface (API) of the service to perform activities of the role, discovering data and behavioral models exposed by the service during this exercise, and configuring a selected set of graphical user interface (GUI) components to represent the discovered data and behavioral models for the activities of the role.

摘要翻译： 用于为服务和角色创建服务客户端的计算机实现的方法（和结构）包括：运行该服务的应用程序编程接口（API）以执行该角色的活动，发现由该服务暴露的数据和行为模型 锻炼和配置所选择的一组图形用户界面（GUI）组件以表示用于角色的活动的发现的数据和行为模型。

公开(公告)号：US20050070597A1

公开(公告)日：2005-03-31

申请号：US10677116

申请日：2003-09-30

申请人： Sangita ,  Atul Kumar ,  Man Singh ,  Suprabhat Ray ,  Girish Jain

发明人： Sangita ,  Atul Kumar ,  Man Singh ,  Suprabhat Ray ,  Girish Jain

IPC分类号： C07D311/58 ,  A61K31/541 ,  A61K31/353 ,  A61K31/452 ,  A61K31/496 ,  A61K31/5377 ,  C07D45/02

CPC分类号： C07D311/58

摘要： The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

摘要翻译： 本发明涉及式I化合物，其中取代基R 2和R 3以反式构型排列：其中：R 1是H或C 1 -C 6烷基; C3-C7环烷基; R 2是苯基，任选地被1至5个独立地选自OH，C 1 -C 6 - 烷基，卤素，硝基，氰基，SH，SR 4， - 3卤代-C 1 -C 6烷基，C 1 C 1-6 - 烷氧基和苯基，其中R 4是C 1 -C 6烷基; R 3是被OR 5取代的苯基，其中R 5具有式（II），（III）或（IV），其中Y选自NHR 4，NR 4，NHCOR 4 >，NHSO 2 R 4，CONHR 4，CONR 4，CONR 4，COOH，COOR 4，SO 2 R 4，SOR 4，SONHR 4，SONR 4 饱和或不饱和的C3-C7杂环，其含有一个或两个独立地选自O，S和N的杂原子，任选被1至3个独立地选自H，OH，卤素， 硝基，氰基，SH，SR 4，三卤代-C 1 -C 6烷基，C 1 -C 6烷基和C 1 -C 6烷氧基，优选NH 4，NR 2 4或氮杂环， 4>如上所定义，并且式I化合物的酯，醚和盐，任选地沿着药学上可接受的赋形剂，其制备方法，以及预防和/或治疗雌激素相关疾病的方法 使用式1化合物的受试者的条件，或其盐，任选地与药物 lly可接受的赋形剂。

公开(公告)号：US20070244161A1

公开(公告)日：2007-10-18

申请号：US11812251

申请日：2007-06-15

申请人： Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

发明人： Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC分类号： A61K31/12 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61P19/08 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

摘要： Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

摘要翻译： 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US20050282863A1

公开(公告)日：2005-12-22

申请号：US11089907

申请日：2005-03-25

申请人： Kanchan Hajela ,  Ashok Jha ,  Man Singh ,  Girish Jain ,  Anil Balapure ,  Anila Dwivedy ,  Bharat Agarwal ,  Puvvada Murthy

发明人： Kanchan Hajela ,  Ashok Jha ,  Man Singh ,  Girish Jain ,  Anil Balapure ,  Anila Dwivedy ,  Bharat Agarwal ,  Puvvada Murthy

IPC分类号： A61K31/407 ,  A61K31/454 ,  C07D209/94 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

CPC分类号： C07D495/04 ,  C07D209/94 ,  C07D491/04

摘要： The invention provides a novel class of N-substituted dihydrobenzothiepino, dihydrobenzoxepino and tetrahydro benzocyclohepta indoles and their pharmaceutically acceptable salts, and methods for of synthesizing these compounds. The invention further comprises pharmaceutical compositions and methods of use for these compounds for the treatment of estrogen related diseases or disorders.

摘要翻译： 本发明提供了一类新型的N-取代的二氢苯并硫代，二氢苯并氧杂吖啉和四氢苯并环庚烯吲哚及其药学上可接受的盐，以及合成这些化合物的方法。 本发明还包括用于这些化合物用于治疗雌激素相关疾病或病症的药物组合物和方法。

公开(公告)号：US20090229350A1

公开(公告)日：2009-09-17

申请号：US12226343

申请日：2007-04-17

申请人： Man Singh

发明人： Man Singh

IPC分类号： G01N11/04 ,  G01N13/02

CPC分类号： G01N13/04

摘要： The present invention provides an apparatus (Oscosurvismeter) for measuring osmotic pressure, surface tension, viscosity and conductance. Oscosurvismeter is made of Borosil glass material for measuring osmotic pressure, specific conductance, viscosity and surface tension of solutions. Solutions of different strengths are taken in two cells/compartments, partitioned by semi permeable membrane (SPM), respectively. Concentration gradient makes the solvent move towards concentrated solution to establish equilibrium that measures osmotic pressure. The Oscosurvismeter saves time and material, and enhances accuracy and precision in measurements, the instrument consists of six parts: Survismeter, Osmometer, Electrode, Metallic clamp, Semipermeable membrane (SPM), and High Potential metallic springs. The high accuracies data are noted with the instrument.

摘要翻译： 本发明提供了一种用于测量渗透压，表面张力，粘度和电导的装置（振荡器）。 振荡器由Borosil玻璃材料制成，用于测量溶液的渗透压，比电导率，粘度和表面张力。 在两个细胞/隔室中分别采用半透膜（SPM）分隔不同强度的溶液。 浓度梯度使溶剂向浓缩溶液移动，建立衡量渗透压的平衡。 Oscosurvismeter可以节省时间和材料，提高测量精度和精度，仪器由六个部分组成：存储器，渗透计，电极，金属夹，半透膜（SPM）和高电位金属弹簧。 仪器注意到高精度数据。