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公开(公告)号:US06673899B2
公开(公告)日:2004-01-06
申请号:US09920804
申请日:2001-08-03
申请人: Susumu Seino , Hideki Yano , Changzheng Wang
发明人: Susumu Seino , Hideki Yano , Changzheng Wang
IPC分类号: C07K14705
CPC分类号: C07K14/705
摘要: The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl—/HCO3— exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl—/HCO3— exchanger, and cells in which the proteins exogenously expressed.
摘要翻译: 本发明公开了包含编码Na +驱动的Cl- / HCO 3 - 交换体的SEQ ID NO:1或NO:3所示的核苷酸序列的DNA,包含SEQ ID NO:2或NO: 4及其包含具有缺失,取代,添加或插入氨基酸的氨基酸序列的同源蛋白质,当在细胞中表达时,这些蛋白质用作Na +驱动的Cl- / HCO 3 - 交换剂,以及其中 外源表达的蛋白质。
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公开(公告)号:US07067265B2
公开(公告)日:2006-06-27
申请号:US10640483
申请日:2003-08-14
申请人: Susumu Seino , Hideki Yano , Changzheng Wang
发明人: Susumu Seino , Hideki Yano , Changzheng Wang
IPC分类号: C12N15/12 , G01N33/566
CPC分类号: C07K14/705
摘要: The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl−/HCO3− exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl−/HCO3− exchanger, and cells in which the proteins exogenously expressed.
摘要翻译: 本发明公开了包含SEQ ID NO:1或NO:3编码Na +和/或NCO 3 / NCO 3的核苷酸序列的DNA 包含SEQ ID NO:2或NO:4所示的氨基酸序列的蛋白质及其同源蛋白质,其包含具有缺失,取代,添加或插入氨基酸的氨基酸序列,其中 当在细胞中表达时,蛋白质用作Na +和/或NCO 3交换剂, 以及蛋白质外源表达的细胞。
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