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公开(公告)号:US20050271670A1
公开(公告)日:2005-12-08
申请号:US11119309
申请日:2005-04-28
申请人: Suzanne Spong , Thomas Neff , Stephen Klaus
发明人: Suzanne Spong , Thomas Neff , Stephen Klaus
IPC分类号: A61K39/395 , A61K45/00 , A61K48/00 , C07K14/71 , C07K16/22 , C12Q1/68 , G01N33/574
CPC分类号: A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/71 , C07K16/22 , G01N33/57438 , G01N2333/475
摘要: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.
摘要翻译: 本发明提供了减少肿瘤存活,扩张和转移的方法。 特别地,本发明提供了减少胰腺肿瘤存活,扩张和转移的方法。 本发明还提供用于该方法的试剂,特别是降低结缔组织生长因子(CTGF)的水平或活性的试剂以及用于鉴定此类试剂的方法。