公开(公告)号：US20150093444A1

公开(公告)日：2015-04-02

申请号：US14354496

申请日：2012-10-23

Applicant: Suzhou Ribo Life Science Co., Ltd.

Inventor： Hongyan Zhang ,  Jun Wang

IPC: A61K47/34 ,  C12N15/113 ,  C08G79/04

CPC classification number: A61K47/34 ,  A61K9/1075 ,  A61K9/5153 ,  A61K31/7105 ,  A61K31/713 ,  C08G63/08 ,  C08G79/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.

Abstract translation: 提供了聚己内酯 - 聚磷酸酯嵌段共聚物，通过嵌段共聚物形成的液体复合物，核酸制剂，共聚物和液体复合物的制备方法，以及在核酸药物递送系统中使用共聚物和液体复合物 。 使用本发明制备的嵌段共聚物具有良好的生物相容性，低细胞毒性和良好的生物降解性。 本发明提供的胶束在水溶液中自组装成纳米颗粒，具有良好的稳定性，生物相容性和生物降解性以及低的细胞毒性。 制备方法简单，重复性高，载体可以保护小核酸如siRNA免受生物降解，可与纳米颗粒的鳞屑结合，可用于治疗不同疾病。 另外，结合靶向组能够特异性识别不同的癌细胞。

公开(公告)号：US09549986B2

公开(公告)日：2017-01-24

申请号：US14354496

申请日：2012-10-23

Applicant: Suzhou Ribo Life Science Co., Ltd.

Inventor： Hongyan Zhang ,  Jun Wang

IPC: A61K47/34 ,  C08G79/04 ,  C12N15/113 ,  C08G63/08 ,  A61K9/107 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/11

CPC classification number: A61K47/34 ,  A61K9/1075 ,  A61K9/5153 ,  A61K31/7105 ,  A61K31/713 ,  C08G63/08 ,  C08G79/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.

Abstract translation: 提供了聚己内酯 - 聚磷酸酯嵌段共聚物，通过嵌段共聚物形成的液体复合物，核酸制剂，共聚物和液体复合物的制备方法，以及在核酸药物递送系统中使用共聚物和液体复合物 。 使用本发明制备的嵌段共聚物具有良好的生物相容性，低细胞毒性和良好的生物降解性。 本发明提供的胶束在水溶液中自组装成纳米颗粒，具有良好的稳定性，生物相容性和生物降解性以及低的细胞毒性。 制备方法简单，重复性高，载体可以保护小核酸如siRNA免受生物降解，可与纳米颗粒的鳞屑结合，可用于治疗不同疾病。 另外，结合靶向组能够特异性识别不同的癌细胞。