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公开(公告)号：US06451762B1
公开(公告)日：2002-09-17
申请号：US09227774
申请日：1999-01-08
IPC分类号： A61K3828
CPC分类号： A61K38/28 , Y10S514/866
摘要： The present invention relates-to protracted acting, water-soluble aggregates of derivatives of human insulin, derivatives of human insulin capable of forming such aggregates, pharmaceutical compositions containing them, and to the use of such aggregates in the treatment of diabetes.
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公开(公告)号：US09260501B2
公开(公告)日：2016-02-16
申请号：US12312132
申请日：2007-10-29
CPC分类号： C07K14/62 , A61K47/48246 , A61K47/64
摘要： Insulins to which there is connected an amino acid oligomer have satisfactory properties.
摘要翻译： 与氨基酸低聚物连接的胰岛素具有令人满意的性能。
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公开(公告)号：US08710000B2
公开(公告)日：2014-04-29
申请号：US12741964
申请日：2008-11-07
摘要： The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to pharmaceutical compositions containing such derivatives and to methods of treating diabetes and hyperglycaemia using the insulin derivatives of the invention.
摘要翻译： 本发明涉及新的人胰岛素衍生物，其在生理pH值下是可溶的并具有延长的作用特征。 本发明还涉及含有这些衍生物的药物组合物和使用本发明的胰岛素衍生物治疗糖尿病和高血糖症的方法。
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公开(公告)号：US20100279931A1
公开(公告)日：2010-11-04
申请号：US12741964
申请日：2008-11-07
摘要： The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to pharmaceutical compositions containing such derivatives and to methods of treating diabetes and hyperglycaemia using the insulin derivatives of the invention.
摘要翻译： 本发明涉及新的人胰岛素衍生物，其在生理pH值下是可溶的并具有延长的作用特征。 本发明还涉及含有这些衍生物的药物组合物和使用本发明的胰岛素衍生物治疗糖尿病和高血糖症的方法。
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公开(公告)号：US20100069605A1
公开(公告)日：2010-03-18
申请号：US12312132
申请日：2007-10-29
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K47/48246 , A61K47/64
摘要： Insulins to which there is connected an amino acid oligomer have satisfactory properties.
摘要翻译： 与氨基酸低聚物连接的胰岛素具有令人满意的性能。
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