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    Process for the preparation of substituted thiazolines and their intermediates
    1.
    发明授权
    Process for the preparation of substituted thiazolines and their intermediates 失效
    制备取代噻唑啉及其中间体的方法

    公开(公告)号：US06894170B2

    公开(公告)日：2005-05-17

    申请号：US10270324

    申请日：2002-10-15

    申请人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    发明人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    IPC分类号： C12P41/00 ,  C07B55/00 ,  C07B57/00 ,  C07C319/02 ,  C07C319/28 ,  C07C323/58 ,  C07D277/12 ,  C07D417/04 ,  C07D277/10

    CPC分类号： C07D417/04 ,  C07C319/02 ,  C07D277/12 ,  C07C323/58

    摘要： Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).

    摘要翻译： 制备式（I）的取代噻唑啉的方法，其中Ar是苯基，萘基，噻吩基，吡啶基或喹啉基，其可以任选地被一个或多个选自卤素，OH，苄氧基，C C 1 -C 4 - 亚烷基，C 1 -C 4 - 烷氧基，COOR 1 - 其中R 1是H或C 1 -C 4 - 烷基，通过将（S）-α-甲基半胱氨酸盐酸盐与 式（II）与式（III）的腈<？in-line-formula description =“In-line formula”end =“lead”？> Ar-CN <？in-line-formula description =“In- 其中Ar如上所定义，或其相应的C 1 -C 4 - 亚烷基亚氨酸酯，其中（S） - 式（II）的α-甲基半胱氨酸盐酸盐在合适的溶剂中与式（III）的腈或相应的C 1 -C 4 - 亚烷基亚氨基酯反应 在pH为6.5t的叔碱存在下进行 o 10在50℃直到回流温度，得到相应的式（I）噻唑啉，以及制备（S）-α-甲基半胱氨酸盐酸盐的方法及其用于制备式（I）的噻唑啉的用途 一世）。

    Process for the preparation of substituted thiazolines and their intermediates
    2.
    发明申请
    Process for the preparation of substituted thiazolines and their intermediates 审中-公开
    制备取代噻唑啉及其中间体的方法

    公开(公告)号：US20050101782A1

    公开(公告)日：2005-05-12

    申请号：US11011110

    申请日：2004-12-15

    申请人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    发明人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    IPC分类号： C12P41/00 ,  C07B55/00 ,  C07B57/00 ,  C07C319/02 ,  C07C319/28 ,  C07C323/58 ,  C07D277/12 ,  C07D417/04

    CPC分类号： C07D417/04 ,  C07C319/02 ,  C07D277/12 ,  C07C323/58

    摘要： Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).

    摘要翻译： 制备式（I）的取代噻唑啉的方法，其中Ar是苯基，萘基，噻吩基，吡啶基或喹啉基，其可以任选地被一个或多个选自卤素，OH，苄氧基，C C 1 -C 4 - 亚烷基，C 1 -C 4 - 烷氧基，COOR 1 - 其中R 1是H或C 1 -C 4 - 烷基，通过将（S）-α-甲基半胱氨酸盐酸盐与 式（II）与式（III）的腈<？in-line-formula description =“In-line formula”end =“lead”？> Ar-CN <？in-line-formula description =“In- 其中Ar如上所定义，或其相应的C 1 -C 4 - 亚烷基亚氨酸酯，其中（S） - 式（II）的α-甲基半胱氨酸盐酸盐在合适的溶剂中与式（III）的腈或相应的C 1 -C 4 - 亚烷基亚氨基酯反应 在pH为6.5的叔碱存在下进行 至10℃，直到回流温度，得到相应的式（I）噻唑啉，以及制备（S）-α-甲基半胱氨酸盐酸盐的方法及其用于制备式（I）的噻唑啉的用途 一世）。

    METHODS AND SYSTEMS FOR MANAGING CONFIGURATION SETTINGS
    4.
    发明申请
    METHODS AND SYSTEMS FOR MANAGING CONFIGURATION SETTINGS 有权
    管理配置设置的方法和系统

    公开(公告)号：US20150220591A1

    公开(公告)日：2015-08-06

    申请号：US14169926

    申请日：2014-01-31

    申请人： Peter Eberlein ,  Alexander Rieder ,  Florian Mueller

    发明人： Peter Eberlein ,  Alexander Rieder ,  Florian Mueller

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30386 ,  G06F17/30312

    摘要： A method for receiving configuration data for a client from a data repository may include sending a request for information pertaining to data stored in the data repository and receiving the data repository information. The method may include identifying a settings repository from the data repository information and requesting configuration data for the client from the identified settings repository. The configuration data may be received from the data repository and stored at the client. The settings at the client may be applied based on the received configuration data.

    摘要翻译： 从数据存储库接收客户端的配置数据的方法可以包括发送关于存储在数据存储库中的数据的信息的请求，并且接收数据存储库信息。 该方法可以包括从数据存储库信息中识别设置存储库，并从所识别的设置存储库请求客户端的配置数据。 配置数据可以从数据存储库接收并存储在客户端。 可以基于所接收的配置数据来应用客户端的设置。