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1.发明申请Method for Treating Proliferative Disorders Associated with Protooncogene Products 审中-公开治疗与原癌基因产物相关的增生性疾病的方法公开(公告)号：US20150094349A1
公开(公告)日：2015-04-02
申请号：US14567245
申请日：2014-12-11
发明人： Zhenjian Du , Kevin Paul Foley
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4164 , A61K31/4166 , A61K31/4178 , A61K31/4188 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/538 , A61K31/675 , A61K31/685
摘要： The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.
摘要翻译： 本发明涉及在有需要的受试者中抑制Hsp90的活性的方法和在受试者中治疗Bcr-Abl，FLT-3，EGFR，c-Kit，B-raf和NPM-ALK相关癌症的方法 需要它。
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公开(公告)号：US20160000756A1
公开(公告)日：2016-01-07
申请号：US14797628
申请日：2015-07-13
发明人： Weiwen Ying , Zhenjian Du , Kevin Paul Foley
IPC分类号： A61K31/4164 , A61K31/5377 , A61K31/52 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/4178 , A61K31/675
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/675 , C07D233/70 , C07D233/84 , C07D233/88 , C07D403/02 , C07D403/04 , C07D403/10 , C07F9/6506
摘要： Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
摘要翻译： 式（I）化合物，包含式（I）化合物的药物组合物和抑制细胞中Hsp90的方法，治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症，其包括给予式（I）化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。
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公开(公告)号：US20140371222A1
公开(公告)日：2014-12-18
申请号：US14473366
申请日：2014-08-29
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Kowalczyk-Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D413/14 , A61K31/4439 , C07D403/04 , A61K31/4196 , A61K31/5377 , C07D405/14 , A61K31/475 , C07D249/12 , C07D403/12 , A61K31/496 , C07D401/14 , A61K31/422
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US09206162B2
公开(公告)日：2015-12-08
申请号：US14685178
申请日：2015-04-13
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Kowalczyk-Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D403/04 , C07D401/14 , C07D413/14 , C07D401/04 , C07D405/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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5.发明申请CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUNDS AND A EGFR INHIBITOR 审中-公开使用HSP90抑制化合物和EGFR抑制剂组合的癌症治疗公开(公告)号：US20160120849A1
公开(公告)日：2016-05-05
申请号：US14930782
申请日：2015-11-03
IPC分类号： A61K31/4196 , A61K45/06 , A61K31/517
CPC分类号： A61K31/4196 , A61K31/517 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical combination comprising an EGFR inhibitor and an Hsp90 inhibitor according to the following formulae a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables in the structural formulae are defined herein. Also provided are methods for treating a proliferative disorder in a subject in need thereof using pharmaceutical combinations disclosed herein.
摘要翻译： 包含根据下式的EGFR抑制剂和Hsp90抑制剂的药物组合物，其互变异构体或其药学上可接受的盐，其中结构式中的变量在本文中定义。 还提供了使用本文公开的药物组合治疗有需要的受试者的增殖性病症的方法。
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公开(公告)号：US09156794B2
公开(公告)日：2015-10-13
申请号：US14103420
申请日：2013-12-11
发明人： Weiwen Ying , Zhenjian Du , Kevin Paul Foley
IPC分类号： C07D403/04 , C07D233/84 , C07D233/70 , C07D233/88 , C07D403/02 , C07D403/10 , C07F9/6506
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/675 , C07D233/70 , C07D233/84 , C07D233/88 , C07D403/02 , C07D403/04 , C07D403/10 , C07F9/6506
摘要： Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
摘要翻译： 式（I）化合物，包含式（I）化合物的药物组合物和抑制细胞中Hsp90的方法，治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症，其包括给予式（I）化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。
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公开(公告)号：US20150266858A1
公开(公告)日：2015-09-24
申请号：US14685178
申请日：2015-04-13
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Kowalczyk-Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D403/04 , C07D413/14 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US09006277B2
公开(公告)日：2015-04-14
申请号：US14473366
申请日：2014-08-29
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Kowalczyk-Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D403/12 , A61K31/4196 , C07D413/14 , C07D401/14 , A61K31/4439 , C07D403/04 , A61K31/422 , C07D405/14 , A61K31/475 , C07D249/12 , A61K31/496 , A61K31/5377
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US08835464B2
公开(公告)日：2014-09-16
申请号：US13857665
申请日：2013-04-05
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Kowalczyk-Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4439 , C07D401/04 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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