公开(公告)号：US20140348828A1

公开(公告)日：2014-11-27

申请号：US14459955

申请日：2014-08-14

Applicant: Syntaxin, Limited

Inventor： Keith Alan FOSTER ,  John Andrew CHADDOCK ,  Conrad Padraig QUINN ,  John Robert PURKISS

IPC: C12N9/52

CPC classification number: C12N9/52 ,  A61K38/1808 ,  A61K38/4886 ,  A61K47/64 ,  C07K16/1282 ,  C07K2319/00 ,  C12Y304/24069

Abstract: The present invention relates to treatment of disease by inhibition of cellular secretory processes, to agents and compositions therefor, and to manufacture of those agents and compositions. The present invention relates particularly, to treatment of disease dependent upon the exocytotic activity of endocrine cells, exocrine cells, inflammatory cells, cells of the immune system, cells of the cardiovascular system and bone cells.

Abstract translation: 本发明涉及通过抑制细胞分泌过程，其药剂及其组合物治疗疾病，以及制备这些药剂和组合物。 本发明特别涉及依赖于内分泌细胞，外分泌细胞，炎症细胞，免疫系统细胞，心血管系统细胞和骨细胞的胞吐活性的疾病的治疗。