公开(公告)号：US20170158639A1

公开(公告)日：2017-06-08

申请号：US15434678

申请日：2017-02-16

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： C07D223/16

CPC分类号： C07D223/16 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07C311/21 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

公开(公告)号：US10508084B2

公开(公告)日：2019-12-17

申请号：US15933804

申请日：2018-03-23

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： C07D223/16 ,  C07C311/21 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

公开(公告)号：US20190062280A1

公开(公告)日：2019-02-28

申请号：US15933804

申请日：2018-03-23

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： C07D223/16 ,  C07D301/00 ,  C07C303/40 ,  C07C67/31 ,  C07C51/09 ,  C07C311/21 ,  C07C51/367

CPC分类号： C07D223/16 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07C311/21 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

公开(公告)号：US09951022B2

公开(公告)日：2018-04-24

申请号：US15434678

申请日：2017-02-16

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： A61K31/55 ,  C07D223/16

CPC分类号： C07D223/16 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07C311/21 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

公开(公告)号：US09598373B2

公开(公告)日：2017-03-21

申请号：US14406568

申请日：2013-06-11

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： C07D223/16 ,  C07C311/21 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07D301/00

CPC分类号： C07D223/16 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07C311/21 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.