-
公开(公告)号:US20210130316A1
公开(公告)日:2021-05-06
申请号:US16473745
申请日:2017-12-19
发明人: Syaulan S. YANG , Kuang-Yuan LEE , Edwin SC WU , Ming-Yu HSIAO , Hsiao-Chun WANG , Meng-Hsien LIU , Peter JS CHIU
IPC分类号: C07D401/04 , C07D221/28
摘要: Novel antagonists of toll-like receptor 4 (TLR-4) are provided. More specifically, the novel antagonists of TLR-4 are derived from morphinan. Further, use of said morphinan derivatives in the treatment of diseases and/or disorders mediated by TLR-4, such as autoimmune diseases, inflammation disease and infectious diseases, is provided. Pharmaceutical compositions including said morphinan derivatives are also provided.
-
公开(公告)号:US20200247761A1
公开(公告)日:2020-08-06
申请号:US16488517
申请日:2018-01-25
发明人: Syaulan S. YANG , Kuang-Yuan LEE , Meng-Hsien LIU , Ming-Yu HSIAO , Huang-Kai PENG , Chiung-Wen WANG , Edwin SC WU , Peter JS CHIU
IPC分类号: C07D241/04 , C07D211/78 , C07D215/36 , C07C311/21 , C07D231/18 , C07D233/38 , C07D207/48 , C07D211/60 , A61P29/00
摘要: The present invention related to novel sulfonamides or amides as TLR-4 antagonists, and pharmaceutical formulations containing the same and the methods of use thereof. Uses of the present novel sulfonamides or amides include, but are not limited to, the prophylaxis and/or treatment of autoimmune, inflammation, or infection related disorders.
-