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    BENZENE FUSED HETEROCYCLIC COMPOUND AND USE THEREOF
    4.
    发明申请
    BENZENE FUSED HETEROCYCLIC COMPOUND AND USE THEREOF 审中-公开

    公开(公告)号：US20200157088A1

    公开(公告)日：2020-05-21

    申请号：US16620702

    申请日：2018-11-30

    申请人： TAIWANJ PHARMACEUTICALS CO., LTD.

    发明人： Syaulan S. YANG ,  Kuang Yuan LEE ,  Yan-Feng JIANG ,  Yu-Shiou FAN ,  Meng Hsien LIU ,  Sheng Hung LIU ,  Jhih-Liang HUANG

    IPC分类号： C07D417/06 ,  C07D401/06 ,  C07D413/06 ,  C07D211/70 ,  C07D403/06 ,  C07D417/14 ,  C07D405/14 ,  C07D405/10

    摘要： The present disclosure provides a benzene fused heterocyclic compound of Formula (I): wherein (A) is a single or double bond; n is 0 or 1; X is —CH2—, O, NR1, or S; A is —C(Ra1)(Ra2)(Ra3) or —N(Ra1)(Ra2), wherein Ra1, Ra2 and Ra3 are independently selected from a group consisting of: H, alkyl, cycloalkyl, heterocyclic alkyl, aryl, heteroaryl, C1-C3 hydrocarbon, —RaaORbb, —C(O)ORaaRbb, —C(O)RaaRbb, —C(O)NRaaRbb, —SO2 RaaRbb and —SO2 NRaaRbb which are optionally substituted by at least one substituent independently selected from a group consisting of: alkyl, cycloalkyl, heterocyclic alkyl, aryl, —Ybb, —ArbbYbb, —ORcc, and —OArbbYbb, wherein Raa, Rbb and Rcc independently are nil, H, halogen, alkyl, or aryl, Ybb is CN or halogen, and Araa and Arbb independently are aryl or heteroaryl; R1 is H or alkyl; R2 is alkyl, cycloalkyl, heterocylic alkyl, aryl, heteroaryl, C1-C6 hydrocarbon optionally substituted by at least one substituent independently selected from a group consisting of: —R2aOR2b, —R2aC(O)OR2bR2c, —R2aC(O)R2bR2c, —R2aC(O)NR2bR2c, —R2aNR2bC(O)NR2cR2d, —R2aNR2bC(O)R2cR2d, —R2aNR2bC(O)OR2cR2d, —R2aSO2R2bR2c, —R2aNR2bSO2NR2cR2d and —R2aSO2NR2bR2c, optionally substituted by at least one substituent independently selected from a group consisting of alkyl, cycloalkyl, heterocyclic alkyl, heteroaryl, and aryl, wherein R2a, R2b, R2c and R2d are independently selected from nil, H, halogen, alkyl, cycloalkyl, heterocyclic alkyl, heteroaryl, aryl or C1-C6 hydrocarbons, optionally substituted by at least one substituent independently selected from a group consisting of —OR2e, ═O, ═S, —SO2R2e, —SO2NR2eR2f, —NR2gSO2NR2eR2f, —NR2gC(O)NR2eR2f, —C(O)NHR2e, —NHC(O)R2e, —NHC(O)OR2e, —NO2, —CO2R2e and —C(O)R2e, wherein R2e, R2f, and R2g independently are H or alkyl.