公开(公告)号：US20140046047A1

公开(公告)日：2014-02-13

申请号：US13951897

申请日：2013-07-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Saku MIYAMOTO ,  Kenji TAKAMI ,  Akira HORINOUCHI

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/158 ,  G16B25/00

Abstract: The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including: (1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

Abstract translation: 本发明提供一种提取器官或组织特异性高表达基因的方法，包括：（1）测定2个以上个体中各器官或组织的特定基因组的表达水平的步骤，（2） 获得（a）所有个体的特定器官或组织中表达水平的最小值的步骤，和（b）每个基因的所有个体的其他器官和组织中的表达水平的最大值，和（3）a 如果上述（a）/（b）比大于1，则将该基因提取为特异性高度表达于特定器官或组织的基因的步骤。通过本发明，提取真正的器官或组织特异性基因 。