公开(公告)号：US12246047B2

公开(公告)日：2025-03-11

申请号：US17227527

申请日：2021-04-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Christian Fiedler ,  Leopold Grillberger ,  Meinhard Hasslacher ,  Barbara Kraus ,  Dominik Mittergradnegger ,  Stefan Reuberger ,  Horst Schafhauser ,  Marian Bendik

IPC: C12N7/02 ,  A61K35/761 ,  C12N7/00

Abstract: Provided herein are methods of producing an adeno-associated virus (AAV) product, methods of purifying adeno-associated virus, and methods of purifying full AAV capsids from a concentrated AAV fraction comprising empty AAV capsids and full AAV capsids.

公开(公告)号：US20210338752A1

公开(公告)日：2021-11-04

申请号：US17227527

申请日：2021-04-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Christian FIEDLER ,  Leopold Grillberger ,  Meinhard Hasslacher ,  Barbara Kraus ,  Dominik Mittergradnegger ,  Stefan Reuberger ,  Horst Schafhauser ,  Marian Bendik

IPC: A61K35/761 ,  C12N7/00

Abstract: Provided herein are methods of producing an adeno-associated virus (AAV) product, methods of purifying adeno-associated virus, and methods of purifying full AAV capsids from a concentrated AAV fraction comprising empty AAV capsids and full AAV capsids.

公开(公告)号：US11000561B2

公开(公告)日：2021-05-11

申请号：US16347082

申请日：2017-11-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Christian Fiedler ,  Leopold Grillberger ,  Meinhard Hasslacher ,  Barbara Kraus ,  Dominik Mittergradnegger ,  Stefan Reuberger ,  Horst Schafhauser ,  Marian Bendik

IPC: C12N7/02 ,  A61K35/761 ,  C12N7/00

Abstract: Provided herein are methods of producing an adeno-associated virus (AAV) product, methods of purifying adeno-associated virus, and methods of purifying full AAV capsids from a concentrated AAV fraction comprising empty AAV capsids and full AAV capsids.