公开(公告)号：US11465994B2

公开(公告)日：2022-10-11

申请号：US16461427

申请日：2017-11-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Martin Teall ,  Kathryn White ,  Stephen Mack ,  Gemma Liwicki ,  Anne Stephenson ,  Louise Dickson

IPC: C07D413/04 ,  C07D311/68 ,  C07D401/12 ,  C07D401/14 ,  C07D407/04

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof wherein Z, R1, R2, R3, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy. The present invention further provides methods of treating at least one disease, disorder, or condition associated with the glutamatergic and GABAergic signalling pathways regulated in full or in part by metabotropic glutamate receptor 7 (mGluR7) by administering a compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject. The compound may be a selective agonist of mGluR7, which modulates the release of at least one neurotransmitter in the subject.

公开(公告)号：US20150376179A1

公开(公告)日：2015-12-31

申请号：US14766520

申请日：2014-02-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： David Livermore ,  Kathryn White ,  Miles Congreve ,  Giles Brown ,  Michael O'Brien

IPC: C07D417/14 ,  A61K31/4545 ,  A61K31/55 ,  A61K45/06 ,  A61K31/454 ,  A61K31/506 ,  C07D413/14 ,  C07D401/14 ,  C07D409/14

CPC classification number: C07D417/14 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.

Abstract translation: 本发明提供式（I）的毒蕈碱M4受体激动剂及其药学上可接受的盐，其中m，n，p，q，R，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物和 它们用于治疗诸如精神分裂症，阿尔茨海默病和各种认知障碍等疾病以及治疗或缓解疼痛。