公开(公告)号：US09464060B2

公开(公告)日：2016-10-11

申请号：US14463780

申请日：2014-08-20

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC分类号： C07D239/34 ,  C07D213/78 ,  C07D213/81 ,  C07C235/52 ,  C07C235/46

CPC分类号： C07D239/34 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C235/46 ,  C07C235/52 ,  C07C255/54 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/78 ,  C07D213/81

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US11465994B2

公开(公告)日：2022-10-11

申请号：US16461427

申请日：2017-11-17

申请人： Takeda Pharmaceutical Company Limited

发明人： Martin Teall ,  Kathryn White ,  Stephen Mack ,  Gemma Liwicki ,  Anne Stephenson ,  Louise Dickson

IPC分类号： C07D413/04 ,  C07D311/68 ,  C07D401/12 ,  C07D401/14 ,  C07D407/04

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof wherein Z, R1, R2, R3, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy. The present invention further provides methods of treating at least one disease, disorder, or condition associated with the glutamatergic and GABAergic signalling pathways regulated in full or in part by metabotropic glutamate receptor 7 (mGluR7) by administering a compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject. The compound may be a selective agonist of mGluR7, which modulates the release of at least one neurotransmitter in the subject.

公开(公告)号：US20190031599A1

公开(公告)日：2019-01-31

申请号：US16072296

申请日：2017-01-24

申请人： Takeda Pharmaceutical Company Limited

发明人： Anne Goldby ,  Gemma Liwicki ,  Stephen Mack ,  Martin Teall ,  Katy White

IPC分类号： C07C233/41 ,  C07C233/23 ,  A61P25/30 ,  A61P25/18 ,  A61P27/16

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a and R4b are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US10100018B2

公开(公告)日：2018-10-16

申请号：US14913135

申请日：2014-08-20

申请人： Takeda Pharmaceutical Company Limited

发明人： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC分类号： C07C235/52 ,  A61P29/00 ,  C07D239/34 ,  C07D213/81 ,  C07C235/46 ,  C07D213/78 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C255/54

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US20190010129A1

公开(公告)日：2019-01-10

申请号：US15999570

申请日：2018-08-20

申请人： Takeda Pharmaceutical Company Limited

发明人： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC分类号： C07D239/34 ,  C07C255/54 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07D213/81 ,  A61K31/277 ,  C07D213/78 ,  C07C235/46 ,  C07C235/52 ,  A61K31/195

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, formula (I) wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.