公开(公告)号：US20190263784A1

公开(公告)日：2019-08-29

申请号：US16342892

申请日：2017-10-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Katsunori NAGAI ,  Takuto KOJIMA ,  Shinichi IMAMURA ,  Masao HIRAKATA

IPC: C07D401/14 ,  A61K31/6615 ,  A61K31/05 ,  A61K31/57 ,  A61K31/09 ,  A61K31/58 ,  A61P35/00 ,  A61P3/00 ,  A61K9/00

Abstract: The present invention relates to N-((3S,4R)-1-((8-chloroquinoxalin-6-yl)carbonyl)-3-(4-fluorophenyl)piperidin-4-yl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide, which is a compound that can be useful for the treatment or prevention of SPT-related diseases including congenital diseases associated with the storage of sphingolipids, such as cancer and Niemann-Pick disease, or a salt thereof.