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公开(公告)号：US20250034141A1
公开(公告)日：2025-01-30
申请号：US18908457
申请日：2024-10-07
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takaharu HIRAYAMA , Yoshiteru ITO , Noriyuki NII , Youichi KAWAKITA , Shinichi IMAMURA
IPC: C07D471/04 , C07D487/04
Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.
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公开(公告)号：US20210115067A1
公开(公告)日：2021-04-22
申请号：US17130297
申请日：2020-12-22
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Youichi KAWAKITA , Takuto KOJIMA , Noriyuki NII , Yoshiteru ITO , Nobuki SAKAUCHI , Hiroshi BANNO , Xin LIU , Koji ONO , Keisuke IMAMURA , Shinichi IMAMURA
IPC: C07D519/00 , A61K31/444 , A61K31/53 , A61K31/5025 , A61K31/519 , A61K31/4985 , A61P35/00
Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].
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公开(公告)号：US20190241566A1
公开(公告)日：2019-08-08
申请号：US16333296
申请日：2017-09-14
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Takashi ICHIKAWA , Shinichi IMAMURA
IPC: C07D473/28 , C07D473/40 , C07D519/00 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D409/14 , C07D405/14 , C07D401/04 , A61P35/00
Abstract: Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.
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Patent Agency Ranking
公开(公告)号：US20190263784A1
公开(公告)日：2019-08-29
申请号：US16342892
申请日：2017-10-17
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Katsunori NAGAI , Takuto KOJIMA , Shinichi IMAMURA , Masao HIRAKATA
IPC: C07D401/14 , A61K31/6615 , A61K31/05 , A61K31/57 , A61K31/09 , A61K31/58 , A61P35/00 , A61P3/00 , A61K9/00
Abstract: The present invention relates to N-((3S,4R)-1-((8-chloroquinoxalin-6-yl)carbonyl)-3-(4-fluorophenyl)piperidin-4-yl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide, which is a compound that can be useful for the treatment or prevention of SPT-related diseases including congenital diseases associated with the storage of sphingolipids, such as cancer and Niemann-Pick disease, or a salt thereof.
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公开(公告)号：US20180170874A1
公开(公告)日：2018-06-21
申请号：US15565891
申请日：2016-04-19
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Yasutomi ASANO , Takuto KOJIMA , Osamu KURASAWA , Tzu-Tshin WONG , Yasuhiro HIRATA , Naoki IWAMURA , Bunnai SAITO , Yuta TANAKA , Ryosuke ARAI , Shinichi IMAMURA , Kazuko YONEMORI , Yasufumi MIYAMOTO , Shuji KITAMURA , Osamu SANO
IPC: C07D211/58 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07D215/42 , C07D401/12 , C07D417/12 , C07D405/06 , C07D413/06 , C07D401/06 , C07D417/06 , C07D401/14 , C07D417/14 , C07D413/14 , C07B59/00 , A61P35/00 , A61P3/00
CPC classification number: C07D211/58 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , A61P3/00 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D215/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , C07F9/6509
Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US20190359587A1
公开(公告)日：2019-11-28
申请号：US16332993
申请日：2017-09-14
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Shinichi IMAMURA
IPC: C07D401/04 , A61P35/00 , C07D409/14 , C07D401/14 , C07D417/14 , C07D407/14
Abstract: Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20190106437A1
公开(公告)日：2019-04-11
申请号：US16094030
申请日：2017-04-27
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Youichi KAWAKITA , Takuto KOJIMA , Noriyuki NII , Yoshiteru ITO , Nobuki SAKAUCHI , Hiroshi BANNO , Xin LIU , Koji ONO , Keisuke IMAMURA , Shinichi IMAMURA
IPC: C07D519/00 , A61P35/00
Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].
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公开(公告)号：US20190062274A1
公开(公告)日：2019-02-28
申请号：US16175144
申请日：2018-10-30
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Yasutomi ASANO , Takuto KOJIMA , Osamu KURASAWA , Tzu-Tshin WONG , Yasuhiro HIRATA , Naoki IWAMURA , Bunnai SAITO , Yuta TANAKA , Ryosuke ARAI , Shinichi IMAMURA , Kazuko YONEMORI , Yasufumi MIYAMOTO , Shuji KITAMURA , Osamu SANO
IPC: C07D211/58 , C07F9/6509 , C07D405/06 , A61P3/00 , A61P35/00 , C07B59/00 , C07D413/14 , C07F5/02 , C07D519/00 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/12 , C07D417/06 , C07D413/06 , C07D409/12 , C07D401/12 , C07D401/06 , C07D215/42 , A61K33/22 , A61K31/661 , A61K31/5355 , A61K31/517 , A61K31/506 , A61K31/498 , A61K31/4709 , A61K31/452 , A61K31/451 , A61K31/4468 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/4433 , A61K31/443 , A61K31/437 , C07D401/14
CPC classification number: C07D211/58 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , A61P3/00 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D215/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , C07F9/6509 , Y02P20/55
Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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