公开(公告)号：US20160015952A1

公开(公告)日：2016-01-21

申请号：US14774385

申请日：2014-03-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshihiro OMACHI ,  Yasuhiro HIRAISHI ,  Masami KUSAKA ,  Shigehiro ASANO ,  Masao NAGAO

IPC: A61M37/00 ,  B29C45/00 ,  B29C45/16 ,  A61K9/70

Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

Abstract translation: 本发明提供一种能够解决微针生产困难，需要高精度的问题，对健康专业人员和患者的时间和精神负担大的问题以及复合多种药物引起的问题的微针补丁。 微针补片包括一个支撑片上竖立的大量药物载体微突起4，每个微突出物4具有在其顶部可体内溶解的药物层5，在药物层5下方具有中间层6，中间层6 含有用于将药物层5粘附到支撑片材的聚合物质，包含单一药物的微注射器4的顶部的药物层5，将保持不同类型药物的微注射物4一起布置在支撑片材2上。