公开(公告)号：US20150037423A1

公开(公告)日：2015-02-05

申请号：US14519979

申请日：2014-10-21

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takashi KURASAWA ,  Yasuko WATANABE ,  Yoshihiro OMACHI

IPC: A61K9/28 ,  A61K9/00 ,  A61K31/4439

CPC classification number: A61K9/2886 ,  A61K9/0056 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5078 ,  A61K31/4439

Abstract: The present invention provides an orally-disintegrating solid preparation such as a tablet produced by tabletting fine granules showing controlled release of a pharmaceutically active ingredient and an additive, and the like, and the orally-disintegrating solid preparation containing fine granules coated with a coating layer containing a polymer affording a casting film having an elongation at break of about 100-about 700%. With the preparation, breakage of fine granules during tabletting can be suppressed in the production of an orally-disintegrating solid preparation containing fine granules showing controlled release of a pharmaceutically active ingredient.

Abstract translation: 本发明提供一种口腔崩解固体制剂，例如通过压制显示药物活性成分和添加剂的受控释放的细颗粒而制成的片剂等，以及包含涂覆有涂层的细颗粒的口腔崩解固体制剂 含有提供约100-约700％断裂伸长率的流延薄膜的聚合物。 通过制备，可以抑制片剂中细颗粒的破裂，生产包含显示控制释放药物活性成分的细颗粒的口腔崩解固体制剂。

公开(公告)号：US20160310412A1

公开(公告)日：2016-10-27

申请号：US15104642

申请日：2014-12-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yutaka TANOUE ,  Yumiko ISHII ,  Yoshihiro OMACHI ,  Tomoyuki MANOSHIRO

IPC: A61K9/00 ,  A61K39/12 ,  A61K47/40 ,  A61K47/26 ,  A61K47/36 ,  A61K39/08 ,  C12N7/00

CPC classification number: A61K9/0021 ,  A61K39/08 ,  A61K39/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K2039/5258 ,  A61K2039/54 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034 ,  Y02A50/386

Abstract: In order to configure a microneedle to be more suitable for administering a vaccine antigen, the present invention is a formulation having a dissolving-type microspike which is used as a microneedle in which a vaccine antigen is stabilized, and which includes a vaccine antigen, an ionic polymer base material, and at least one species selected from the group consisting of a non-reducing sugar, a sugar alcohol, cyclodextrin, and a surfactant.

Abstract translation: 为了将微针配置为更适合于施用疫苗抗原，本发明是具有溶解型小珠的制剂，其用作疫苗抗原稳定化的微针，其包含疫苗抗原， 离子聚合物基材，以及选自非还原糖，糖醇，环糊精和表面活性剂中的至少一种。

公开(公告)号：US20160015952A1

公开(公告)日：2016-01-21

申请号：US14774385

申请日：2014-03-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshihiro OMACHI ,  Yasuhiro HIRAISHI ,  Masami KUSAKA ,  Shigehiro ASANO ,  Masao NAGAO

IPC: A61M37/00 ,  B29C45/00 ,  B29C45/16 ,  A61K9/70

Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

Abstract translation: 本发明提供一种能够解决微针生产困难，需要高精度的问题，对健康专业人员和患者的时间和精神负担大的问题以及复合多种药物引起的问题的微针补丁。 微针补片包括一个支撑片上竖立的大量药物载体微突起4，每个微突出物4具有在其顶部可体内溶解的药物层5，在药物层5下方具有中间层6，中间层6 含有用于将药物层5粘附到支撑片材的聚合物质，包含单一药物的微注射器4的顶部的药物层5，将保持不同类型药物的微注射物4一起布置在支撑片材2上。