公开(公告)号：US20150094296A1

公开(公告)日：2015-04-02

申请号：US14388452

申请日：2013-03-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tetsuya Tsukamoto ,  Yusuke Ohba ,  Takafumi Yukawa ,  Hiroyuki Nagamiya ,  Taku Kamei ,  Norihito Tokunaga ,  Morihisa Saitoh ,  Atsutoshi Okabe

IPC: C07D403/04 ,  C07D401/14 ,  C07D413/14 ,  C07D491/107 ,  C07D403/14 ,  C07D405/14

CPC classification number: C07D403/04 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/107

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US20140350260A1

公开(公告)日：2014-11-27

申请号：US14454993

申请日：2014-08-08

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Minoru Nakamura ,  Yoshihide Tomata ,  Takafumi Takai ,  Yasutaka Hoashi ,  Yuichi Kajita ,  Tetsuya Tsukamoto ,  Makoto Kamata

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。 由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

公开(公告)号：US09187453B2

公开(公告)日：2015-11-17

申请号：US14388452

申请日：2013-03-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tetsuya Tsukamoto ,  Yusuke Ohba ,  Takafumi Yukawa ,  Hiroyuki Nagamiya ,  Taku Kamei ,  Norihito Tokunaga ,  Morihisa Saitoh

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/506 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D491/107

CPC classification number: C07D403/04 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/107

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.