公开(公告)号：US20180319816A1

公开(公告)日：2018-11-08

申请号：US16034002

申请日：2018-07-12

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Kazuhiro MIWA ,  Tsuyoshi SASAKI ,  Fumiya KOMURA

IPC: C07D495/04 ,  C07D409/12 ,  C07D333/38

Abstract: The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

公开(公告)号：US20170210753A1

公开(公告)日：2017-07-27

申请号：US15481505

申请日：2017-04-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Koichiro FUKUOKA ,  Kazuhiro MIWA ,  Tsuyoshi SASAKI ,  Fumiya KOMURA

IPC: C07D495/04 ,  C07D409/12 ,  C07D333/38

CPC classification number: C07D495/04 ,  C07D333/38 ,  C07D409/12

Abstract: The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

公开(公告)号：US20220204525A1

公开(公告)日：2022-06-30

申请号：US17694635

申请日：2022-03-14

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Koichiro FUKUOKA ,  Kazuhiro MIWA ,  Tsuyoshi SASAKI ,  Fumiya KOMURA

IPC: C07D495/04 ,  C07D333/38 ,  C07D409/12

Abstract: The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrirnidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.