公开(公告)号：US11773108B2

公开(公告)日：2023-10-03

申请号：US17751035

申请日：2022-05-23

申请人： TARO PHARMACEUTICALS INC.

发明人： Curtis Harwig ,  Jeremy D. Pettigrew ,  Jennifer Cross ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Karthikeyan Iyanar

IPC分类号： C07D493/10 ,  C07D231/54 ,  C07D401/08 ,  C07D403/08 ,  C07D417/08 ,  A61P29/00

CPC分类号： C07D493/10 ,  A61P29/00 ,  C07D231/54 ,  C07D401/08 ,  C07D403/08 ,  C07D417/08

摘要： Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：US11420962B2

公开(公告)日：2022-08-23

申请号：US17045626

申请日：2019-04-05

申请人： TARO PHARMACEUTICALS INC.

发明人： Curtis Harwig ,  Jeremy D. Pettigrew ,  Jennifer Cross ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Samir Satish Kher

IPC分类号： C07D263/56 ,  C07D231/54 ,  C07D239/74 ,  C07D241/42 ,  C07D261/20 ,  C07D209/08 ,  C07D277/64 ,  C07D285/14 ,  A61K31/437 ,  A61P29/00 ,  C07D413/06 ,  C07D239/84 ,  C07D401/08 ,  C07D403/04 ,  C07D403/08 ,  C07D405/12

摘要： Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：US11352367B2

公开(公告)日：2022-06-07

申请号：US17045675

申请日：2019-04-05

申请人： TARO PHARMACEUTICALS INC.

发明人： Curtis Harwig ,  Jeremy D. Pettigrew ,  Jennifer Cross ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Karthikeyan Iyanar

IPC分类号： C07D493/10 ,  C07D231/54 ,  C07D401/08 ,  C07D403/08 ,  C07D417/08 ,  A61P29/00

摘要： Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.