公开(公告)号：US10513528B2

公开(公告)日：2019-12-24

申请号：US16079469

申请日：2017-02-23

申请人： TAXIS PHARMACEUTICALS, INC. ,  Ravi Ponnaiah ,  Sudhakar Sunkari ,  Anil Kumar Soni ,  Savi Rami Reddy Athunuri ,  Thrisulapani Korrakuti ,  Pullarao Seelam

发明人： Ravi Ponnaiah ,  Sudhakar Sunkari ,  Anil Kumar Soni ,  Savi Rami Reddy Athunuri ,  Thrisulapani Korrakuti ,  Pullarao Seelam ,  Ajit K. Parhi

IPC分类号： C07D513/02 ,  C07D513/04 ,  C07C65/24 ,  C07C35/00 ,  C07C43/00 ,  C07C43/225 ,  C07D211/62 ,  C07C63/00

摘要： The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.

公开(公告)号：US20210139508A1

公开(公告)日：2021-05-13

申请号：US16997716

申请日：2020-08-19

申请人： TAXIS PHARMACEUTICALS, INC.

发明人： Sanjeevani Ghone ,  Fu-An Kang ,  Nareshkumar Jain ,  Ajit K. Parhi ,  Ravi Ponnaiah ,  Anil Kumar Soni ,  Siva Rami Reddy Athunuri ,  Thrisulapani Korrakuti ,  Pullarao Seelam

IPC分类号： C07D513/04 ,  B01J23/44

摘要： The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709:

公开(公告)号：US11845742B2

公开(公告)日：2023-12-19

申请号：US16763521

申请日：2018-11-13

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  TAXIS PHARMACEUTICALS, INC.

发明人： Edmond J. LaVoie ,  Hye Yeon Sagong ,  Ajit K. Parhi

IPC分类号： C07D409/12 ,  C07D209/14 ,  C07D209/70 ,  A61K45/06

CPC分类号： C07D409/12 ,  C07D209/14 ,  C07D209/70 ,  A61K45/06

摘要： Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

公开(公告)号：US20190031624A1

公开(公告)日：2019-01-31

申请号：US16046696

申请日：2018-07-26

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  TAXIS PHARMACEUTICALS, INC.

发明人： Edmond J. LaVoie ,  Ajit K. Parhi ,  Yangsheng Sun

IPC分类号： C07D251/08 ,  C07C335/32 ,  C07D213/70 ,  C07D209/08 ,  C07D215/12 ,  C07D307/79 ,  C07D333/54 ,  A61P31/04

摘要： Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.

公开(公告)号：US20200325124A1

公开(公告)日：2020-10-15

申请号：US16763521

申请日：2018-11-13

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  TAXIS PHARMACEUTICALS, INC.

发明人： Edmond J. LaVoie ,  Hye Yeon Sagong ,  Ajit K. Parhi

IPC分类号： C07D409/12 ,  C07D209/14 ,  C07D209/70

摘要： Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.