公开(公告)号：US20190120794A1

公开(公告)日：2019-04-25

申请号：US16087833

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Sachio TSUBOIKE ,  Susumu HARATANI ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: G01N27/72 ,  G01N33/543 ,  C12Q1/6825

CPC classification number: G01N27/72 ,  C12Q1/6816 ,  C12Q1/6825 ,  G01N27/745 ,  G01N33/54373 ,  C12Q2565/607

Abstract: A chemical sensor that enables high detection accuracy that includes a soft-magnetic-material film, a magnetoresistance-effect element, a first film disposed over the soft-magnetic-material film, and a second film disposed over the magnetoresistance-effect element, wherein, when viewed from a direction perpendicular to the film surface of the soft-magnetic-material film, the soft-magnetic-material film is disposed at least partially so as not to overlap the magnetoresistance-effect element; when viewed from the direction perpendicular to the film surface of the soft-magnetic-material film, the magnetoresistance-effect element is disposed at least partially so as not to overlap the soft-magnetic-material film; and the second film has higher solubility in a specific liquid than the first film.

公开(公告)号：US20190064046A1

公开(公告)日：2019-02-28

申请号：US16089122

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Susumu HARATANI ,  Sachio TSUBOIKE ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: G01N15/06

Abstract: What provided is a biosensor including: a substrate having a surface with first and second regions adjacent each other; a magnetoresistance effect element disposed on the first region; a soft magnetic thin film on the second region; a protective film disposed on both the first region and the second region, covering a surface of the soft magnetic thin film, and disposed on the top part of the second region and contains an affinity substance recognizing the biomolecule on the outer surface of the second region exclusively; and an MR cover film disposed on at least the top part of the first region, disposed on the protective film above the magnetoresistance effect element, and being free of the affinity substance, wherein the soft magnetic thin film transmits an in-plane component of a stray magnetic field of magnetic beads to the magnetoresistance effect element.

公开(公告)号：US20190224671A1

公开(公告)日：2019-07-25

申请号：US16088988

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Susumu HARATANI ,  Sachio TSUBOIKE ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: B01L3/00 ,  C12Q1/6825 ,  G01N27/00

Abstract: A biosensor includes a substrate having a surface in which a first region and a second region disposed adjacent to the first region are formed; a magnetoresistance effect element that is disposed on at least the first region and is configured such that a resistance value detected according to an input magnetic field varies; a protective film that is disposed on both the first region and the second region and covers a surface of the magnetoresistance effect element, and is disposed on the top part of the second region and contains an affinity substance that allows recognition of the biomolecules on the outer surface only on the second region; and an adsorption prevention film that is disposed on at least the top part of the first region and is substantially free of the affinity substance, wherein the protective film and the adsorption prevention film are made of different materials.

公开(公告)号：US20190113479A1

公开(公告)日：2019-04-18

申请号：US16087836

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Sachio TSUBOIKE ,  Susumu HARATANI ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: G01N27/72 ,  G01N33/543 ,  C12Q1/6825

Abstract: To provide a chemical sensor that enables high detection accuracy. A chemical sensor includes a substrate, two or more magnetoresistance-effect elements disposed side by side in a substrate in-plane direction over the substrate, a first film disposed over a region between the magnetoresistance-effect elements adjacent to each other, and a second film disposed over the magnetoresistance-effect elements, wherein the second film has higher solubility in a specific liquid than the first film.

公开(公告)号：US20190154676A1

公开(公告)日：2019-05-23

申请号：US15752210

申请日：2016-07-22

Applicant: TDK CORPORATION

Inventor： Haruki YUGA ,  Seigo ZAIMA ,  Takashi KIKUKAWA ,  Sachio TSUBOIKE

IPC: G01N33/543

Abstract: A detection system includes a detection device including a space, defined by a wall surface, into which a liquid containing a biomolecular label and a liquid containing magnetic beads are introduced and a magnetic sensor having a surface forming a portion of the wall surface, wherein at least some of the magnetic beads bind to the biomolecular label immobilized on the surface of the magnetic sensor or to a molecule near the biomolecular label immobilized on the surface of the magnetic sensor; and a first magnetic-field applying mechanism that applies a magnetic field in a direction in which the magnetic beads are moved away from the surface of the magnetic sensor.

公开(公告)号：US20190128882A1

公开(公告)日：2019-05-02

申请号：US16089007

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Susumu HARATANI ,  Sachio TSUBOIKE ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: G01N33/543 ,  G01N27/74

Abstract: What provided is a biosensor including: a substrate having a surface with first and second regions adjacent to each other; a magnetoresistance effect element that is disposed at least on the first region and is configured for a detected resistance value to be changed based on an input magnetic field; a protective film that is disposed on both the first region and the second region, covers a surface of the magnetoresistance effect element, is disposed on the top part of the first region and contains an affinity substance capable of recognizing the biomolecule on the outer surface of the first region exclusively; and an adsorption prevention film that is disposed on at least the top part of the second region and is substantially free of the affinity substance, wherein the protective film and the adsorption prevention film are made of different materials.

公开(公告)号：US20190107512A1

公开(公告)日：2019-04-11

申请号：US16087794

申请日：2017-03-24

Applicant: TDK CORPORATION

Inventor： Sachio TSUBOIKE ,  Susumu HARATANI ,  Sumiko KITAGAWA ,  Takashi KIKUKAWA ,  Haruki YUGA

IPC: G01N27/74 ,  G01R33/09 ,  G01R33/12

Abstract: A chemical sensor that enables high detection accuracy. A chemical sensor includes a substrate, a magnetoresistance-effect element disposed over the substrate, a first film disposed over the magnetoresistance-effect element, and a second film disposed in a region in the vicinity of the magnetoresistance-effect element or over a region in the vicinity of the magnetoresistance-effect element, wherein the second film has higher solubility in a specific liquid than the first film.