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公开(公告)号:US10799864B2
公开(公告)日:2020-10-13
申请号:US16087836
申请日:2017-03-24
Applicant: TDK CORPORATION
Inventor: Sachio Tsuboike , Susumu Haratani , Sumiko Kitagawa , Takashi Kikukawa , Haruki Yuga
IPC: B01L3/00 , B82Y25/00 , G01N15/06 , G01N27/72 , G01N27/74 , G01R33/09 , G01R33/12 , C12Q1/6825 , G01N33/543 , G01N27/00 , G01N15/00
Abstract: To provide a chemical sensor that enables high detection accuracy. A chemical sensor includes a substrate, two or more magnetoresistance-effect elements disposed side by side in a substrate in-plane direction over the substrate, a first film disposed over a region between the magnetoresistance-effect elements adjacent to each other, and a second film disposed over the magnetoresistance-effect elements, wherein the second film has higher solubility in a specific liquid than the first film.
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公开(公告)号:US10948395B2
公开(公告)日:2021-03-16
申请号:US16089122
申请日:2017-03-24
Applicant: TDK CORPORATION
Inventor: Susumu Haratani , Sachio Tsuboike , Sumiko Kitagawa , Takashi Kikukawa , Haruki Yuga
IPC: G01N15/06 , G01N33/543 , G01N27/74 , G01N15/00
Abstract: What provided is a biosensor including: a substrate having a surface with first and second regions adjacent each other; a magnetoresistance effect element disposed on the first region; a soft magnetic thin film on the second region; a protective film disposed on both the first region and the second region, covering a surface of the soft magnetic thin film, and disposed on the top part of the second region and contains an affinity substance recognizing the biomolecule on the outer surface of the second region exclusively; and an MR cover film disposed on at least the top part of the first region, disposed on the protective film above the magnetoresistance effect element, and being free of the affinity substance, wherein the soft magnetic thin film transmits an in-plane component of a stray magnetic field of magnetic beads to the magnetoresistance effect element.
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公开(公告)号:US10801993B2
公开(公告)日:2020-10-13
申请号:US16087833
申请日:2017-03-24
Applicant: TDK CORPORATION
Inventor: Sachio Tsuboike , Susumu Haratani , Sumiko Kitagawa , Takashi Kikukawa , Haruki Yuga
IPC: G01N27/72 , C12Q1/6816 , G01N27/74 , C12Q1/6825 , G01N33/543
Abstract: A chemical sensor that enables high detection accuracy that includes a soft-magnetic-material film, a magnetoresistance-effect element, a first film disposed over the soft-magnetic-material film, and a second film disposed over the magnetoresistance-effect element, wherein, when viewed from a direction perpendicular to the film surface of the soft-magnetic-material film, the soft-magnetic-material film is disposed at least partially so as not to overlap the magnetoresistance-effect element; when viewed from the direction perpendicular to the film surface of the soft-magnetic-material film, the magnetoresistance-effect element is disposed at least partially so as not to overlap the soft-magnetic-material film; and the second film has higher solubility in a specific liquid than the first film.
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公开(公告)号:US10799863B2
公开(公告)日:2020-10-13
申请号:US16087794
申请日:2017-03-24
Applicant: TDK CORPORATION
Inventor: Sachio Tsuboike , Susumu Haratani , Sumiko Kitagawa , Takashi Kikukawa , Haruki Yuga
IPC: G01N33/44 , B01L3/00 , B82Y25/00 , G01N15/06 , G01N27/72 , G01N27/74 , G01R33/09 , G01R33/12 , C12Q1/6825 , G01N33/543 , G01N27/00 , G01N15/00
Abstract: A chemical sensor that enables high detection accuracy. A chemical sensor includes a substrate, a magnetoresistance-effect element disposed over the substrate, a first film disposed over the magnetoresistance-effect element, and a second film disposed in a region in the vicinity of the magnetoresistance-effect element or over a region in the vicinity of the magnetoresistance-effect element, wherein the second film has higher solubility in a specific liquid than the first film.
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公开(公告)号:US20170160187A1
公开(公告)日:2017-06-08
申请号:US14962040
申请日:2015-12-08
Applicant: TDK Corporation
Inventor: Celine Hu , Sumiko Kitagawa , Koki Kawamura , Po-Kang Wang
IPC: G01N15/14
CPC classification number: G01N15/0612 , G01N2015/0065
Abstract: An apparatus for detecting the presence of a specific molecular species in a mixture of species operates by first flowing the mixture through microfluidic channels onto a substrate to which the specific species bonds, then attaching electromagnetic radiation scattering particles to the bonded species, then scanning the substrate with a uniform flux of laser radiation and relating the intensity of the scattered portion of the radiation to the density of particles captured by the molecular species affixed to the substrate. The substrate can be scanned either by: 1. applying oscillating mirrors to reflect the laser beam and uniformly scan the substrate; 2. moving the entire laser relative to the substrate so that its beam uniformly scans the substrate; 3. moving the entire substrate uniformly in the x-y plane while keeping the laser and its beam fixed.
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