公开(公告)号：US20190098895A1

公开(公告)日：2019-04-04

申请号：US16082751

申请日：2017-03-08

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Avi SCHROEDER ,  Avishai KARNY

IPC: A01N25/28 ,  A01N25/30 ,  A01N57/20

Abstract: Provided is a formulation including an agriculturally acceptable carrier and liposomes including a lipid membrane and an intraliposomal aqueous core. The liposome has a diameter in the range of between 100 nm to 300 nm and the lipid membrane includes at least one liposome forming phospholipid. The lipid membrane may include two or more phospholipids. At least one of the two or more phospholipids may be a liposome forming lipid. Further, at least one of the two or more phospholipids may be characterized by one or more of the following features: (a) it has an unsaturated lipid tail; (b) it includes a polar head group; (c) it includes an acidic head group. Further provided are methods of using the formulation for agricultural treatment and kits for preparing and using such formulations.

公开(公告)号：US20200367491A1

公开(公告)日：2020-11-26

申请号：US16987282

申请日：2020-08-06

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Avi SCHROEDER ,  Avishai KARNY

IPC: A01N25/28 ,  A01N25/30 ,  A61K9/127 ,  A01N57/20

Abstract: Provided is a formulation including an agriculturally acceptable carrier and liposomes including a lipid membrane and an intraliposomal aqueous core. The liposome has a diameter in the range of between 100 nm to 300 nm and the lipid membrane includes at least one liposome forming phospholipid. The lipid membrane may include two or more phospholipids. At least one of the two or more phospholipids may be a liposome forming lipid. Further, at least one of the two or more phospholipids may be characterized by one or more of the following features: (a) it has an unsaturated lipid tail; (b) it includes a polar head group; (c) it includes an acidic head group. Further provided are methods of using the formulation for agricultural treatment and kits for preparing and using such formulations.

公开(公告)号：US20150037404A1

公开(公告)日：2015-02-05

申请号：US14520542

申请日：2014-10-22

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

Inventor： Yechezkel BARENHOLZ ,  Dorit NITZAN ,  Izhak ETSION ,  Avi SCHROEDER ,  Grigory HALPERIN ,  Sarit SIVAN

IPC: A61K9/127 ,  A61K9/00

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/685 ,  A61L27/50 ,  A61L2430/24

Abstract: A method for lubricating a joint of a mammal by administering into a cavity of the joint a composition of liposomes that are multilamellar vesicles (MLV) dispersed in a fluid medium, the liposomes having a mean diameter of between about 0.8 μm to about 10 μm and including membranes of at least one glycerophospholipid (GPL) having two C12-C16 hydrocarbon chains which are the same or different. These membranes have a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being at a temperature of about 20° C. to about 39° C. and being lower than the temperature of the joint.

Abstract translation: 一种用于润滑哺乳动物关节的方法，该方法是将分散在流体培养基中的多层囊泡（MLV）的脂质体组合物施用到接合腔中，所述脂质体的平均直径为约0.8μm至约10μm， 包括具有两个相同或不同的两个C 12 -C 16烃链的至少一种甘油磷脂（GPL）的膜。 这些膜具有其中发生固体有序（SO）至液体无序（LD）相变的相变温度，相变温度在约20℃至约39℃的温度并低于温度 的联合。