公开(公告)号：US20150290214A1

公开(公告)日：2015-10-15

申请号：US14438413

申请日：2013-10-24

Applicant: Zeev GROSS ,  Adi HABER ,  Itzchak ANGEL ,  TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Zeev Gross ,  Adi Haber ,  Itzchak Angel

IPC: A61K31/555

CPC classification number: A61K31/555 ,  A61K31/409 ,  A61K38/41 ,  C07D487/22

Abstract: An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.

Abstract translation: 本发明的一个实施方案提供了有效量的角role的过渡金属络合物，其旋光异构体或其药学上可接受的盐在治疗患有眼睛和/或肾脏的受试者的眼睛和/或肾脏疾病中的用途 糖尿病。 本发明的一个实施方案进一步提供了用于降低患有糖尿病的受试者的血清葡萄糖和血清甘油三酯水平的糠醛，其旋光异构体或其药学上可接受的盐的过渡金属络合物的用途。

公开(公告)号：US09572816B2

公开(公告)日：2017-02-21

申请号：US14438413

申请日：2013-10-24

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Zeev Gross ,  Adi Haber ,  Itzchak Angel

IPC: A61K31/555 ,  A61K31/409 ,  A61K38/41 ,  C07D487/22

CPC classification number: A61K31/555 ,  A61K31/409 ,  A61K38/41 ,  C07D487/22

Abstract: An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.

Abstract translation: 本发明的一个实施方案提供了有效量的角role的过渡金属络合物，其旋光异构体或其药学上可接受的盐在治疗患有眼睛和/或肾脏的受试者的眼睛和/或肾脏疾病中的用途 糖尿病。 本发明的一个实施方案进一步提供了用于降低患有糖尿病的受试者的血清葡萄糖和血清甘油三酯水平的糠醛，其旋光异构体或其药学上可接受的盐的过渡金属络合物的用途。