公开(公告)号：US20180353567A1

公开(公告)日：2018-12-13

申请号：US15768428

申请日：2016-10-17

Applicant: THOMAS JEFFERSON UNIVERSITY ,  TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Jeffrey L. Benovic ,  Richard Carr, III ,  Douglas G. Tilley

IPC: A61K38/10 ,  A61P9/00 ,  A61K9/00 ,  A61K9/127 ,  A61K31/138

CPC classification number: A61K38/10 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/138 ,  A61P9/00

Abstract: A pharmaceutical composition and methods of administering the same for treatment of cardiovascular disease comprising a pepducin having a sequence SEQ ID No. 1, wherein said composition stimulates cardiomyocyte contractility and activating the β2AR/β-arrestin signaling pathway.

公开(公告)号：US11542555B2

公开(公告)日：2023-01-03

申请号：US15929784

申请日：2020-05-21

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68 ,  A61K48/00

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US11236389B2

公开(公告)日：2022-02-01

申请号：US15115807

申请日：2015-01-30

Applicant: Temple University of the Commonwealth System of Higher Education

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68 ,  A61K48/00

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US20230073246A1

公开(公告)日：2023-03-09

申请号：US17938209

申请日：2022-10-05

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US20210017600A1

公开(公告)日：2021-01-21

申请号：US15929784

申请日：2020-05-21

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.