公开(公告)号：US11542555B2

公开(公告)日：2023-01-03

申请号：US15929784

申请日：2020-05-21

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68 ,  A61K48/00

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US20230073246A1

公开(公告)日：2023-03-09

申请号：US17938209

申请日：2022-10-05

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US20210017600A1

公开(公告)日：2021-01-21

申请号：US15929784

申请日：2020-05-21

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US11236389B2

公开(公告)日：2022-02-01

申请号：US15115807

申请日：2015-01-30

Applicant: Temple University of the Commonwealth System of Higher Education

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68 ,  A61K48/00

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US11235029B2

公开(公告)日：2022-02-01

申请号：US15916494

申请日：2018-03-09

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Johns Hopkins Technology Ventures ,  Universita di Napoli Federico II

Inventor： Alessandro Cannavo ,  Ning Feng ,  Giuseppe Rengo ,  Nazareno Paolocci ,  Walter J. Koch

IPC: A61K38/18 ,  A61K31/166 ,  A61K31/353 ,  A61K31/404 ,  A61K31/138 ,  A61P9/04 ,  C07K14/71 ,  C07K14/475 ,  A61K39/00

Abstract: The present invention relates to compositions and methods for the treatment of heart failure.

公开(公告)号：US20180256683A1

公开(公告)日：2018-09-13

申请号：US15916494

申请日：2018-03-09

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Johns Hopkins Technology Ventures ,  Universita di Napoli Federico II

Inventor： Alessandro Cannavo ,  Ning Feng ,  Giuseppe Rengo ,  Nazareno Paolocci ,  Walter J. Koch

IPC: A61K38/18 ,  A61K31/353 ,  A61K31/166 ,  A61K31/138 ,  A61K31/404 ,  A61P9/04

CPC classification number: A61K38/185 ,  A61K31/138 ,  A61K31/166 ,  A61K31/353 ,  A61K31/404 ,  A61K2039/505 ,  A61P9/04

Abstract: The present invention relates to compositions and methods for the treatment of heart failure.