公开(公告)号：US20240358765A1

公开(公告)日：2024-10-31

申请号：US18767576

申请日：2024-07-09

Applicant: Terumo Kabushiki Kaisha ,  Osaka University

Inventor： Hidetoshi EGUCHI ,  Yoshito TOMIMARU ,  Shigeru MIYAGAWA ,  Keisuke TOYA ,  Fumiya OHASHI

IPC: A61K35/34 ,  A61P1/16 ,  C12N5/077

CPC classification number: A61K35/34 ,  A61P1/16 ,  C12N5/0658 ,  C12N2502/28

Abstract: A composition comprising skeletal myoblasts for treating liver dysfunction or improving liver function, in which the liver dysfunction can be hepatitis, liver fibrosis, liver cirrhosis, liver cancer, or liver failure. The composition can be used for promoting the proliferation of liver cells, regeneration of the liver tissue and/or angiogenesis, and providing a method for treating liver dysfunction, including a step of treating applying the composition to a site exhibiting liver dysfunction.

公开(公告)号：US20250082690A1

公开(公告)日：2025-03-13

申请号：US18767567

申请日：2024-07-09

Applicant: TERUMO KABUSHIKI KAISHA ,  OSAKA UNIVERSITY

Inventor： Hidetoshi EGUCHI ,  Yoshito TOMIMARU ,  Shigeru MIYAGAWA ,  Keisuke TOYA ,  Fumiya OHASHI

IPC: A61K35/34 ,  A61P1/16 ,  C12N5/077

Abstract: A sheet-shaped cell culture comprising skeletal myoblasts for treating liver dysfunction or improving liver function. A method for producing the sheet-shaped cell culture, including a step of seeding a cell population comprising skeletal myoblasts on a culture substrate, a step of forming a sheet of the cell population into a sheet to form a sheet-shaped cell culture, and a step of detaching the formed sheet-shaped cell culture from the culture substrate. A method for treating liver dysfunction, including a step of applying the sheet-shaped cell culture to a site exhibiting the liver dysfunction.