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公开(公告)号：US20220257925A1
公开(公告)日：2022-08-18
申请号：US17622511
申请日：2020-06-26
发明人： Rachael Scott-Young , James Fallon , Andrew Wise , Alexander Thompson , Paul Randall Stoddart , William Lloyd Hart , Karina Brady
摘要： Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.
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公开(公告)号：US20190381318A1
公开(公告)日：2019-12-19
申请号：US16555724
申请日：2019-08-29
发明人： Nicholas Sinclair , Hugh McDermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
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公开(公告)号：US20190381317A1
公开(公告)日：2019-12-19
申请号：US16555376
申请日：2019-08-29
发明人： Nicholas Sinclair , Hugh McDermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
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公开(公告)号：US10463860B2
公开(公告)日：2019-11-05
申请号：US16195294
申请日：2018-11-19
发明人： Nicholas Sinclair , Hugh Mcdermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
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公开(公告)号：US20220265216A1
公开(公告)日：2022-08-25
申请号：US17616788
申请日：2020-06-05
发明人： James Fallon
摘要： A method of detecting neural activity in a nerve is disclosed. A first electrical signal is received from a first pair of electrodes. A second electrical signal is received from a second pair of electrodes, the second pair of electrodes being spaced from the first pair of electrodes along the nerve. A correlation analysis is applied between the first and second electrical signals, including for at least one non-zero lag time, to obtain correlation data. From the correlation data, at least one neural signal is detected, indicative of neural activity in the nerve. The neural signal corresponds to increased correlation between the first and second signals at the at least one non-zero lag time.
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公开(公告)号：US20190143120A1
公开(公告)日：2019-05-16
申请号：US16195294
申请日：2018-11-19
发明人： Nicholas Sinclair , Hugh McDermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
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公开(公告)号：US11413452B2
公开(公告)日：2022-08-16
申请号：US16844286
申请日：2020-04-09
摘要： The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject. In addition, the present disclosure relates to a method for treating or preventing a chronic inflammatory condition in a human subject in need thereof.
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公开(公告)号：US20200230400A1
公开(公告)日：2020-07-23
申请号：US16844286
申请日：2020-04-09
摘要： The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject. In addition, the present disclosure relates to a method for treating or preventing a chronic inflammatory condition in a human subject in need thereof.
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公开(公告)号：US20230018722A1
公开(公告)日：2023-01-19
申请号：US17786207
申请日：2020-12-16
发明人： Sophie Morgan , Joel Villalobos , James Fallon
摘要： Methods and systems are disclosed for modulating glycaemia in a patient in which an activating stimulation signal is applied at an activating location at the vagus nerve, the activating stimulation signal configured to evoke a neural response in the vagus nerve; and a blocking stimulation signal is applied at a blocking location at the vagus nerve, the blocking stimulation signal configured to inhibit transmission of the evoked neural response along the vagus nerve past the blocking location; to produce unidirectional vagal nerve stimulation, the unidirectional vagal nerve stimulation being effective to modulate glycaemia in the patient.
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10.发明申请公开(公告)号：US20190261912A1
公开(公告)日：2019-08-29
申请号：US16335907
申请日：2017-09-29
发明人： Robert K. Shepherd , John Furness , James Fallon , Sophie Payne , Owen Burns
摘要： Detecting of a disorder associated with impaired barrier function in the gastrointestinal tract of a subject is described, including through determining bioimpedance across a subject's gastrointestinal tract wall and detecting impaired barrier function based on bioimpedance. An electrical signal is measured between first and second electrodes, at least the first electrode being located in a gastrointestinal tract of the body and one or more characteristics are determined based on the measured electrical signal. The one or more characteristics can comprise hallmarks of impaired barrier function such as leakiness and/or permeability of the gastrointestinal tract and can provide an indication of inflammatory bowel disease and/or gut inflammation.
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