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    MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY
    1.
    发明申请
    MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY 有权
    控制MYOSIN表达和MYOFIBER识别的微RNA

    公开(公告)号：US20130245092A1

    公开(公告)日：2013-09-19

    申请号：US13796884

    申请日：2013-03-12

    申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    发明人： ERIC N. OLSON ,  EVA VAN ROOIJ

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10

    摘要： The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.

    摘要翻译： 本发明涉及两种抑制快速骨骼肌收缩蛋白基因的微小RNA（miR-499和miR-208b）的鉴定。 miR-499和/或miR-208b的表达可用于抑制快速纤维基因并激活慢纤维基因以治疗肌肉骨骼疾病。 提出miR-499和/或miR-208b的抑制作为心脏肥大，心肌梗死和/或心力衰竭的治疗。 还公开了包含miR-499和miR-208b功能的拮抗剂和激动剂的药物组合物。