公开(公告)号：US20230288432A1

公开(公告)日：2023-09-14

申请号：US18014850

申请日：2021-07-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Marc I. DIAMOND ,  Jaime VAQUER-ALICEA ,  Gianna C. MAGGIORE

IPC: G01N33/68 ,  C12N5/071 ,  C12N15/86 ,  G01N33/542

CPC classification number: G01N33/6896 ,  C12N5/0686 ,  C12N15/86 ,  G01N33/542 ,  G01N2800/2814 ,  C12N2503/00 ,  C12N2740/15043 ,  G01N2333/4709 ,  G01N2333/4704

Abstract: The present disclosure provides methods for the identification, characterization and ranking of putative tau monomer stabilizing agents. Specifically, the disclosure provides methods for assessing the capability of a test compound to stabilize a tau monomer, methods of prioritizing a plurality of test compounds from a library identified as tau monomer stabilizing agents, methods of screening a test compound library to identify tau monomer stabilizing agents, and a kit providing the reagents to perform the described methods.