公开(公告)号：US20170313739A1

公开(公告)日：2017-11-02

申请号：US15653397

申请日：2017-07-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Susan L. MOOBERRY ,  Jiangnan PENG ,  April L. RISINGER ,  Jing LI

IPC: C07J71/00 ,  C07D493/08 ,  A61K36/894 ,  A61K31/585

CPC classification number: C07J71/001 ,  A61K31/585 ,  A61K36/894 ,  C07D493/08 ,  C07J71/0005

Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.

公开(公告)号：US20160257707A1

公开(公告)日：2016-09-08

申请号：US15153470

申请日：2016-05-12

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Susan L. MOOBERRY ,  Jiangnan PENG ,  April L. RISINGER ,  Jing LI

IPC: C07J71/00 ,  A61K36/894 ,  A61K31/585

CPC classification number: C07J71/001 ,  A61K31/585 ,  A61K36/894 ,  C07D493/08 ,  C07J71/0005

Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.

Abstract translation: 本发明提供了环氧卡那霉素微管稳定剂及其作为抗增殖微管稳定剂的用途。

公开(公告)号：US20240043393A1

公开(公告)日：2024-02-08

申请号：US18158046

申请日：2023-01-23

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D277/34 ,  C07D513/04 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D417/14

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20140357608A1

公开(公告)日：2014-12-04

申请号：US14096876

申请日：2013-12-04

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Susan L. MOOBERRY ,  Jiangnan PENG ,  April L. RISINGER ,  Jing LI

IPC: C07J71/00

CPC classification number: C07J71/001 ,  A61K31/585 ,  A61K36/894 ,  C07D493/08 ,  C07J71/0005

Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.

Abstract translation: 本发明提供了环氧卡那霉素微管稳定剂及其作为抗增殖微管稳定剂的用途。

公开(公告)号：US20220356158A1

公开(公告)日：2022-11-10

申请号：US17191305

申请日：2021-03-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.