公开(公告)号：US12065416B2

公开(公告)日：2024-08-20

申请号：US18158046

申请日：2023-01-23

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Boyu Zhong ,  Lijun Sun ,  Heping Shi ,  Jing Li ,  Chuo Chen ,  Zhijian Chen

IPC: C07D277/34 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39 ,  A61K45/06 ,  C07D277/36 ,  C07D277/40 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D277/34 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39 ,  A61K45/06 ,  C07D277/36 ,  C07D277/40 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/4709 ,  A61K2300/00 ,  A61K31/426 ,  A61K2300/00 ,  A61K31/4365 ,  A61K2300/00 ,  A61K31/429 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/381 ,  A61K2300/00 ,  A61K31/427 ,  A61K2300/00 ,  A61K31/433 ,  A61K2300/00 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/506 ,  A61K2300/00

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US12049439B2

公开(公告)日：2024-07-30

申请号：US17463011

申请日：2021-08-31

Applicant: OrsoBio, Inc.

Inventor： Julie Farand ,  Joshua A. Kaplan ,  Gregory Notte ,  Casey Lockwood Olen ,  Michael Sangi ,  David Sperandio

IPC: C07C323/25 ,  A61K31/18 ,  A61P1/16 ,  C07C311/08 ,  C07C311/13 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/46 ,  C07C313/06 ,  C07C323/30 ,  C07C323/31 ,  C07D205/04 ,  C07D207/48 ,  C07D213/89 ,  C07D231/18 ,  C07D235/00 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D279/12 ,  C07D295/116 ,  C07D305/08 ,  C07D309/08 ,  C07D335/02 ,  C07D451/02 ,  C07D493/08 ,  C07F9/50

CPC classification number: C07C323/25 ,  A61K31/18 ,  A61P1/16 ,  C07C311/08 ,  C07C311/13 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/46 ,  C07C313/06 ,  C07C323/30 ,  C07C323/31 ,  C07D205/04 ,  C07D207/48 ,  C07D213/89 ,  C07D231/18 ,  C07D235/00 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D279/12 ,  C07D295/116 ,  C07D305/08 ,  C07D309/08 ,  C07D335/02 ,  C07D451/02 ,  C07D493/08 ,  C07F9/5022

Abstract: Provided is a compound of Formula (I):






wherein the variable groups are defined herein.

公开(公告)号：US20240002350A1

公开(公告)日：2024-01-04

申请号：US18037406

申请日：2021-11-17

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES/DPI/NIH

Inventor： Sally Ellen MORGANROTH ,  Valerian KAGAN ,  Jinming ZHAO ,  Ganesha RAI ,  Hulya BAYIR ,  Yulia TYURINA ,  Haider DAR ,  Tamil ANTHONYMUTHU ,  Joel GREENBERGER ,  Michael EPPERLY ,  Diane LUCI ,  Juan MARUGAN ,  Anton SIMEONOV ,  Alexey V. ZAKHAROV ,  Adam YASGAR ,  Andrew AMOSCATO

IPC: C07D239/42 ,  C07D233/84 ,  C07D233/88 ,  C07D403/12 ,  C07C335/16 ,  C07D401/04 ,  C07D237/20 ,  C07D249/10 ,  C07D263/46 ,  C07D263/48 ,  C07D277/36 ,  C07D277/42 ,  A61P25/00

CPC classification number: C07D239/42 ,  C07D233/84 ,  C07D233/88 ,  C07D403/12 ,  C07C335/16 ,  C07D401/04 ,  C07D237/20 ,  C07D249/10 ,  C07D263/46 ,  C07D263/48 ,  C07D277/36 ,  C07D277/42 ,  A61P25/00

Abstract: Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions.

公开(公告)号：US11760735B2

公开(公告)日：2023-09-19

申请号：US17711205

申请日：2022-04-01

Applicant: Novartis AG

Inventor： Gary Glick ,  Shomir Ghosh ,  William R. Roush

IPC: C07D263/46 ,  A61K31/41 ,  C07D333/34 ,  C07D405/12 ,  C07D417/12 ,  C07D295/096 ,  C07D213/34 ,  C07D307/64 ,  C07D311/54 ,  C07D213/71 ,  C07D277/36 ,  C07C317/22

CPC classification number: C07D263/46 ,  A61K31/41 ,  C07C317/22 ,  C07D213/34 ,  C07D213/71 ,  C07D277/36 ,  C07D295/096 ,  C07D307/64 ,  C07D311/54 ,  C07D333/34 ,  C07D405/12 ,  C07D417/12 ,  C07C2603/10

Abstract: In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein.

公开(公告)号：US20230180761A1

公开(公告)日：2023-06-15

申请号：US18166601

申请日：2023-02-09

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： RONALD J. HEEMSTRA ,  RONALD ROSS, JR. ,  KYLE A. DEKORVER ,  KAITLYN GRAY ,  DANIEL I. KNUEPPEL ,  PETER VEDNOR ,  TIMOTHY P. MARTIN ,  JOSEPH D. ECKELBARGER ,  JOHN F. DAEUBLE, SR. ,  RICKY HUNTER ,  DAVID A. DEMETER ,  TONY K. TRULLINGER ,  ERICH W. BAUM ,  ZOLTAN L. BENKO ,  NAKYEN CHOY ,  GARY D. CROUSE ,  FANGZHENG LI ,  JEFFREY NISSEN ,  MONICA B. OLSON ,  MICHELLE RIENER ,  THOMAS C. SPARKS ,  FRANK J. WESSELS ,  MAURICE C. YAP

IPC: A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

CPC classification number: A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20230143250A1

公开(公告)日：2023-05-11

申请号：US17891436

申请日：2022-08-19

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Guoqiang Wang ,  Jun Ma ,  Brett Granger ,  Jiang Long ,  Bin Wang ,  Sourav Ghorai ,  Jing He ,  Yong He ,  Xuechao Xing ,  Ruichao Shen ,  Yat Sun Or

IPC: C07D265/36 ,  C07D277/36 ,  C07C311/29 ,  C07D217/20 ,  C07D471/04 ,  C07D209/18 ,  C07D209/44 ,  C07D417/12 ,  C07D417/04 ,  C07D307/81

CPC classification number: C07D265/36 ,  C07D277/36 ,  C07C311/29 ,  C07D217/20 ,  C07D471/04 ,  C07D209/18 ,  C07D209/44 ,  C07D417/12 ,  C07D417/04 ,  C07D307/81

Abstract: The present invention provides compounds of Formula (I),




pharmaceutical compositions comprising these compounds and methods of using these compounds to provides a method of modulating a HSD17B13 protein for treatment of metabolic disease or liver condition, The present invention relates generally to compounds and pharmaceutical compositions useful as 17β-HSD13 inhibitors. Specifically, the present invention relates to compounds useful as inhibitors of 17β-HSD13 and methods for their preparation and use.

公开(公告)号：US10047066B2

公开(公告)日：2018-08-14

申请号：US12744860

申请日：2008-12-01

Applicant: Mario Mautino ,  Firoz Jaipuri ,  Agnieszka Marcinowicz-Flick ,  Tanay Kesharwani ,  Jesse Waldo

Inventor： Mario Mautino ,  Firoz Jaipuri ,  Agnieszka Marcinowicz-Flick ,  Tanay Kesharwani ,  Jesse Waldo

IPC: A61K31/5375 ,  A61K31/135 ,  A61K31/404 ,  A61K31/381 ,  A61K31/505 ,  C07D209/14 ,  C07D405/12 ,  C07D333/56 ,  A61K31/138 ,  A61K31/506 ,  C07C259/06 ,  C07C311/48 ,  C07C327/44 ,  C07C327/48 ,  C07C333/20 ,  C07D209/18 ,  C07D213/40 ,  C07D215/26 ,  C07D253/07 ,  C07D261/20 ,  C07D263/22 ,  C07D277/36 ,  C07D279/06 ,  C07D307/81 ,  C07D333/58 ,  C07D333/60 ,  C07D335/06 ,  C07D401/06 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  C07D277/64 ,  C07D307/80 ,  A61P37/00 ,  A61K31/4045 ,  C07D403/12 ,  C07D401/12 ,  A61K31/4709 ,  C07D413/12 ,  A61K31/423 ,  C07C333/04 ,  A61K31/27 ,  C07D213/53 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/36 ,  A61K31/47 ,  A61K31/357 ,  A61K31/428

CPC classification number: C07D333/56 ,  A61K31/138 ,  A61K31/506 ,  C07C259/06 ,  C07C311/48 ,  C07C327/44 ,  C07C327/48 ,  C07C333/20 ,  C07D209/14 ,  C07D209/18 ,  C07D213/40 ,  C07D215/26 ,  C07D253/07 ,  C07D261/20 ,  C07D263/22 ,  C07D277/36 ,  C07D277/64 ,  C07D279/06 ,  C07D307/80 ,  C07D307/81 ,  C07D333/58 ,  C07D333/60 ,  C07D335/06 ,  C07D401/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/409 ,  Y02A50/465

Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

公开(公告)号：US20180155319A1

公开(公告)日：2018-06-07

申请号：US15711680

申请日：2017-09-21

Applicant: Robert D. Ladner ,  Bruno Giethlen

Inventor： Robert D. Ladner ,  Bruno Giethlen

IPC: C07D401/06 ,  C07D277/34 ,  C07D231/56 ,  C07D401/12 ,  C07D403/06 ,  C07D215/26 ,  C07D471/04 ,  C07D265/18 ,  C07D498/04 ,  C07D277/36 ,  C07D211/88 ,  C07D239/54

CPC classification number: C07D401/06 ,  C07D211/88 ,  C07D215/26 ,  C07D231/56 ,  C07D239/54 ,  C07D265/18 ,  C07D277/34 ,  C07D277/36 ,  C07D401/12 ,  C07D403/06 ,  C07D471/04 ,  C07D498/04

Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

公开(公告)号：US09795140B2

公开(公告)日：2017-10-24

申请号：US15092646

申请日：2016-04-07

Applicant: Dow AgroSciences LLC

Inventor： Timothy P. Martin ,  Joseph D. Eckelbarger ,  Ronald Ross, Jr. ,  Kyle DeKorver ,  Ronald J. Heemstra ,  Daniel I. Knueppel ,  Peter Vednor ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich Baum ,  Zoltan Benko ,  Nakyen Choy ,  Gary Crouse ,  John F. Daeuble, Sr. ,  Fangzheng Li ,  Jeff Nissen ,  Michelle Riener ,  Tom Sparks ,  Frank Wessels ,  Maurice Yap

IPC: A01N53/00 ,  A01N43/90 ,  C07D207/273 ,  A01N43/82 ,  C07D307/33 ,  C07D277/36 ,  C07D263/26 ,  C07D261/12 ,  C07D333/48 ,  C07D307/52 ,  C07D277/30 ,  C07D213/56 ,  C07C237/22 ,  C07D333/60 ,  C07D233/80 ,  C07D487/04 ,  A01N43/707 ,  A01N43/653 ,  A01N43/60 ,  A01N43/40 ,  A01N41/10 ,  A01N37/34 ,  A01N37/22 ,  C07D253/07 ,  C07D241/20 ,  C07C317/14 ,  C07C233/65 ,  C07C233/63 ,  C07D209/49 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/10 ,  C07D207/452 ,  C07C255/29 ,  C07C255/57 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07C255/46 ,  C07D213/75 ,  C07C255/60 ,  C07C259/10 ,  C07D213/81 ,  C07D213/84 ,  C07D309/14 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D231/12 ,  C07D331/04 ,  C07D231/56 ,  C07D333/36 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07D249/08 ,  C07C331/12 ,  C07D215/38

CPC classification number: A01N53/00 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C237/22 ,  C07C237/42 ,  C07C255/29 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07C271/28 ,  C07C271/66 ,  C07C311/08 ,  C07C311/46 ,  C07C317/14 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/10 ,  C07D207/273 ,  C07D207/452 ,  C07D209/49 ,  C07D213/56 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07D215/38 ,  C07D231/12 ,  C07D231/56 ,  C07D233/36 ,  C07D233/80 ,  C07D235/30 ,  C07D241/20 ,  C07D249/08 ,  C07D253/07 ,  C07D261/12 ,  C07D263/26 ,  C07D277/30 ,  C07D277/36 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D307/33 ,  C07D307/52 ,  C07D309/14 ,  C07D331/04 ,  C07D333/36 ,  C07D333/48 ,  C07D333/60 ,  C07D487/04

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20170183333A1

公开(公告)日：2017-06-29

申请号：US15227395

申请日：2016-08-03

Applicant: ARDEA BIOSCIENCES, INC.

Inventor： Andreas Maderna ,  Jean-Michel Vernier ,  Dinesh Barawkar ,  Varaprasad Chamakura ,  Hassan El Abdellaoul ,  Zhi Hong

IPC: C07D417/04 ,  C07C311/10 ,  C07C311/09 ,  C07C311/14 ,  C07C311/28 ,  C07D307/64 ,  C07D277/54 ,  C07D261/10 ,  C07D231/18 ,  C07D277/36 ,  C07D233/84 ,  C07D333/34 ,  C07D207/36 ,  C07C311/21 ,  C07D231/12 ,  C07D213/38 ,  C07C311/32 ,  C07D295/088 ,  C07C311/08

CPC classification number: C07D417/04 ,  A61K31/18 ,  A61K31/34 ,  A61K31/381 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/426 ,  A61K31/433 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  C07B2200/07 ,  C07C311/08 ,  C07C311/09 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/28 ,  C07C311/29 ,  C07C311/32 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/36 ,  C07D211/54 ,  C07D213/38 ,  C07D213/42 ,  C07D231/12 ,  C07D231/18 ,  C07D233/84 ,  C07D261/10 ,  C07D277/36 ,  C07D277/54 ,  C07D285/04 ,  C07D295/088 ,  C07D295/13 ,  C07D307/64 ,  C07D333/34

Abstract: This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.