公开(公告)号：US10975142B2

公开(公告)日：2021-04-13

申请号：US16244097

申请日：2019-01-09

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Philipp Erich Scherer ,  Jiyoung Park ,  Zhiqiang An

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/46 ,  C07K16/00 ,  C07K16/18 ,  A61K33/24 ,  A61K31/555

Abstract: Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alpha3 chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.