公开(公告)号：US20250019465A1

公开(公告)日：2025-01-16

申请号：US18709365

申请日：2022-11-14

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Kiyoshi ARIIZUMI ,  Jin-Sung CHUNG ,  Ponciano D. CRUZ, Jr.

IPC: C07K16/44 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30

Abstract: Provided herein are single domain antibodies (sdAbs) having a specific affinity for a rare heparan sulfate moiety which can be used to disrupt DC-HIL function to reduce and prevent cancer progression and metastasis. Compositions and methods of use thereof are also provided for use of these sdAbs to treat cancer and cancer metastasis in a subject in need thereof.

公开(公告)号：US20180064809A1

公开(公告)日：2018-03-08

申请号：US15556985

申请日：2016-03-09

Applicant: The Board of Regents of the University of Texas System

Inventor： Kiyoshi ARIIZUMI ,  Ponciano CRUZ

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A61K39/395 ,  A61K35/15 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/28 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/76 ,  C07K2319/30 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5743 ,  G01N2800/52 ,  G01N2800/56

Abstract: The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.